Venlafaxine Retard Helvepharm
Venlafaxine Retard Helvepharm Uses, Dosage, Side Effects, Food Interaction and all others data.
Venlafaxine Retard Helvepharm is the principal active metabolite of venlafaxine. The exact mechanism is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the CNS, through inhibition of their reuptake.
Venlafaxine Retard Helvepharm is a selective serotonin and norepinephrine reuptake inhibitor. It lacks significant activity on muscarinic-cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. Venlafaxine Retard Helvepharm does not appear to exert activity against calcium, chloride, potassium and sodium ion channels and also lacks monoamine oxidase (MAO) inhibitory activity. It was also shown to lack significant activity again the cardiac potassium channel, hERG, in vitro. Compared to other SNRIs, desvenlafaxine undergoes simple metabolism, has a low risk of drug-drug interactions and does not have to be extensively titrated to reach a therapeutic dose.
Trade Name | Venlafaxine Retard Helvepharm |
Availability | Prescription only |
Generic | Desvenlafaxine |
Desvenlafaxine Other Names | Desvenlafaxina, Desvenlafaxine |
Related Drugs | Rexulti, sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Prozac |
Type | |
Formula | C16H25NO2 |
Weight | Average: 263.3752 Monoisotopic: 263.188529049 |
Protein binding | Protein binding is 30% and this is independent of drug concentration. |
Groups | Approved, Investigational |
Therapeutic Class | Serotonin-norepinephrine reuptake inhibitor (SNRI) |
Manufacturer | |
Available Country | Switzerland |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Venlafaxine Retard Helvepharm, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used for the treatment of major depressive disorder (MDD). The efficacy of Venlafaxine Retard Helvepharm has been established in four short-term (8-week, placebo-controlled studies) and two maintenance studies in adult outpatients who met DSM-IV criteria for major depressive disorder.
Venlafaxine Retard Helvepharm is also used to associated treatment for these conditions: Hot Flushes, Major Depressive Disorder (MDD)
How Venlafaxine Retard Helvepharm works
Venlafaxine Retard Helvepharm, the active metabolite of venlafaxine, is a selective serotonin and norepinephrine reuptake inhibitor. Venlafaxine Retard Helvepharm inhibits neurotransmitter reuptake in serotonin, norepinephrine, and dopamine transporters. Venlafaxine Retard Helvepharm inhibits serotonin transporters with 10 times the affinity of norepinephrine transporters, and dopamine transporters with the lowest affinity. In vitro, desvenlafaxine has no inhibition of monoamine oxidase, and almost no affinity for muscarinic, cholinergic, H1-histaminergic, and alpha1-adrenergic receptors.
Dosage
Venlafaxine Retard Helvepharm dosage
The recommended dose for Venlafaxine Retard Helvepharmis 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. Venlafaxine Retard Helvepharm should be taken at approximately the same time each day. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.In clinical studies, doses of 10 mg to 400 mg per day were studied.
In clinical studies, doses of 50 mg to 400 mg per day were shown to be effective, although no additional benefit was demonstrated at doses greater than 50 mg per day and adverse reactions and discontinuations were more frequent at higher doses.
The 25 mg per day dose is intended for a gradual reduction in dose when discontinuing treatment. When discontinuing therapy, gradual dose reduction is recommended whenever possible to minimize discontinuation symptoms
Side Effects
Suicidal thinking/ behaviour, HTN, mydriasis, seizure, hyponatraemia, interstitial lung disease and eosinophilic pneumonia; nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, sexual function disorders in males (e.g. anorgasmia, decreased libido, abnormal orgasm, delayed ejaculation, erectile dysfunction, ejaculation disorder, ejaculation failure, sexual dysfunction).
Toxicity
Venlafaxine Retard Helvepharm is excreted in breast milk and as a result, nursing mothers must either stop the drug or stop breast feeding depending on the risks and benefit to mother and child.
Precaution
Patient with pre-existing HTN or other conditions that may be compromised by increased BP, raised intraocular pressure, personal or family history of mania or hypomania; CV, cerebrovascular or lipid metabolism disorders; seizure disorder. Avoid abrupt withdrawal. Renal and moderate to severe hepatic impairment. Pregnancy and lactation.
Interaction
Increased risk of bleeding with aspirin or other NSAIDs, warfarin and other anticoagulants.
Food Interaction
- Avoid alcohol.
- Avoid St. John's Wort.
- Take with or without food. The absorption is unaffected by food.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Venlafaxine Retard Helvepharm Hypertension interaction
[Moderate] Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure.
Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension.
Blood pressure should be assessed prior to initiating treatment and monitored regularly.
The dose should be reduced or discontinued if necessary.
Venlafaxine Retard Helvepharm Drug Interaction
Major: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, duloxetine, escitalopram, lithium, lisdexamfetamine, bupropion, sertralineModerate: aripiprazole, lamotrigine, lurasidone, pregabalin, quetiapine, alprazolam, cetirizineUnknown: omega-3 polyunsaturated fatty acids, metoprolol, cyanocobalamin, ascorbic acid, cholecalciferol
Venlafaxine Retard Helvepharm Disease Interaction
Major: depression, renal diseaseModerate: glaucoma, hypertension, hyponatremia, mania, seizures, urinary tract obstruction
Volume of Distribution
3.4L/kg.
Elimination Route
Oral bioavailability is approximately 80% and is unaffected by food. Peak plasma concentration is reached in 7.5 hours.
Half Life
The mean terminal half life is 11.1 hours and may be prolonged in patients with renal and/or moderate to severe hepatic impairment.
Elimination Route
Venlafaxine Retard Helvepharm is mainly excreted in the urine. 45% of the dose is unchanged in the urine, 19% is excreted as a glucuronide metabolite, and 4. No dosage adjustment is necessary for gender, ethnicity, food, or combination with other psychotropics.
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Concurrent use or within 14 days of discontinuing MAOIs (e.g. linezolid, IV methylene blue). Initiation of MAOI at least 7 days after discontinuing desvenlafaxine.
Special Warning
Hepatic impairment (Moderate to severe): 50 mg daily. Max: 100 mg once daily.
Renal Impairment:
- CrCl <30 or ESRD: 25 mg daily or 50 mg every other day. Supplemental doses should not be given after dialysis.
- CrCl (30-50): Max 50 mg once daily.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Venlafaxine Retard Helvepharm
Venlafaxine Retard Helvepharm contains Desvenlafaxine see full prescribing information from innovator Venlafaxine Retard Helvepharm Monograph, Venlafaxine Retard Helvepharm MSDS, Venlafaxine Retard Helvepharm FDA label
FAQ
What is Venlafaxine Retard Helvepharm used for?
Venlafaxine Retard Helvepharm is used to treat depression. Venlafaxine Retard Helvepharm is in a class of medications called selective serotonin and Venlafaxine Retard Helvepharm is a medication used to treat depression. It is recommended that the need for further treatment be occasionally reassessed.
How safe is Venlafaxine Retard Helvepharm?
Safety results indicate that Venlafaxine Retard Helvepharm treatment is generally safe and well tolerated.
How does Venlafaxine Retard Helvepharm work?
Venlafaxine Retard Helvepharm works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.
What are the common side effects of Venlafaxine Retard Helvepharm?
Common side effects of Venlafaxine Retard Helvepharm are include:
Drowsiness, dizziness, nausea, dry mouth, constipation, loss of appetite, weight loss, blurred vision, nervousness, trouble sleeping, or excessive sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Is Venlafaxine Retard Helvepharm safe during pregnancy?
Venlafaxine Retard Helvepharm should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. A pregnancy exposure registry is available.
Is Venlafaxine Retard Helvepharm safe during breastfeeding?
Modest doses of Venlafaxine Retard Helvepharm are excreted into breastmilk, but serum drug levels of breastfed infants are less than 10% of simultaneous maternal levels. Total Venlafaxine Retard Helvepharm exposure of breastfed infants is about half of that experienced by breastfed infants whose mothers are taking Venlafaxine Retard Helvepharm.
Can I drink alcohol with Venlafaxine Retard Helvepharm?
You should avoid or limit the use of alcohol while being treated with Venlafaxine Retard Helvepharm.
Can I drive after taking Venlafaxine Retard Helvepharm ?
You should avoid driving a car or operating machinery.
When is the best time to take Venlafaxine Retard Helvepharm?
Venlafaxine Retard Helvepharm is usually taken once a day with or without food. Take Venlafaxine Retard Helvepharm at around the same time every day.
How long does Venlafaxine Retard Helvepharm take to work ?
Venlafaxine Retard Helvepharm may show some improvement within the first 1-2 weeks.
Can I take Venlafaxine Retard Helvepharm for a long time?
There are no known problems associated with long term use of Venlafaxine Retard Helvepharm. It is a safe and effective medication when used as directed.
How long can I take Venlafaxine Retard Helvepharm?
Clinical guidelines for depression treatment recommend that you keep taking your antidepressant for 4 to 9 months after your depression symptoms improve.
Who should not take Venlafaxine Retard Helvepharm?
You should not use Venlafaxine Retard Helvepharm if you are allergic to Venlafaxine Retard Helvepharm. Do not use Venlafaxine Retard Helvepharm within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Can I overdose on Venlafaxine Retard Helvepharm ?
Venlafaxine Retard Helvepharm can cause delayed onset seizures. There is also a risk of serotonin toxicity in overdose. There are active metabolites, so symptoms can be prolonged.
Does Venlafaxine Retard Helvepharm affect fertility?
While Venlafaxine Retard Helvepharm may or may not affect fertility for the woman, it is important to note that antidepressants typically reduce sex drive.
Does Venlafaxine Retard Helvepharm cause high blood pressure?
Venlafaxine Retard Helvepharm may increase blood pressure. Your blood pressure should be checked regularly while you are taking this medication.
Is Venlafaxine Retard Helvepharm good for anxiety?
Venlafaxine Retard Helvepharm is not FDA approved to treat anxiety.
Can Venlafaxine Retard Helvepharm affect my kidneys?
Any medication, if taken without consultation with your physician, can cause kidney damage.