Vermol
Vermol Uses, Dosage, Side Effects, Food Interaction and all others data.
Vermol is a synthetic derivative of benzimidazole with a potent anthelmintic activity against the most common nematodes and some cestodes. It is highly effective against ascariasis, enterobiasis, trichuriasis and hookworm infections. It is equally effective in single or in mixed infections. The effect of the drug is due to its ability to inhibit glucose uptake irreversibly but it does not affect blood glucose concentration in the host, even in high doses. Vermol does not necessitate any dosage calculation since the same dosage is used for children and adults. It can be taken at any time and no special procedures such as purging, use of laxatives and/or dietary changes are required. Parasite immobilization and death occur slowly and clearance from the gastro-intestinal tract may not be completed up to 3 days after administration.
Vermol is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Vermol is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.
| Trade Name | Vermol |
| Availability | Prescription only |
| Generic | Mebendazole |
| Mebendazole Other Names | MBDZ, Mebendazol, Mébendazole, Mebendazole, Mebendazolum |
| Related Drugs | metronidazole, Flagyl, albendazole, nitazoxanide, praziquantel, piperazine, pyrantel, Albenza, Alinia |
| Weight | 100mg/5ml, 500mg |
| Type | Suspension, Tablet |
| Formula | C16H13N3O3 |
| Weight | Average: 295.2927 Monoisotopic: 295.095691297 |
| Protein binding | 90-95% |
| Groups | Approved, Vet approved |
| Therapeutic Class | Anti-helminthic |
| Manufacturer | W,woodward Pakistan (pvt) Ltd, |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Vermol is used for the treatment of pinworm (Enterobius vermicularis), round worm (Ascaris lumbricoides), hookworm (Ancylostoma duodenale and Necator americanus), whip worm (Trichuris trichiura), tape worm (Taenia solium and taenia saginata) and threadworm (Strongyloides stercoralis) in single or mixed infections
Vermol is also used to associated treatment for these conditions: Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection
How Vermol works
Vermol causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Dosage
Vermol dosage
Vermol 100 mg tablet and suspension: This have the same dosage schedule applies to adults & children.
Enterobiasis: A single tablet or 1 teaspoonful of the suspension.
Ascariasis, Ancylostomiasis, Trichuriasis: 2 tablets, one in the morning, the other in the afternoon for 3 consecutive days or 1 teaspoonful in the morning & 1 teaspoonful in the afternoon for 3 consecutive days
Taeniasis & strongyloidiasis:
- Adults: 2 tablets twice daily for 3 consecutive days.
- Children: 1 tablet twice daily or 1 teaspoonful twice daily for 3 consecutive days.
Vermol 500 mg tablet: One Vermol 500 mg tablet in a single intake regardless of body weight, for all nematode and some cestode infestations. The same dosage applies to adults and children age two years and above.
May be taken with or without food.
Side Effects
Vermol is well tolerated by adults and children. It has virtually no side effects. Transient abdominal pain and diarrhoea have been reported only rarely, in case of massive infestation and expulsion of worms.
Toxicity
Acute oral toxicity (LD50): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.
Precaution
Hepatic impairment. Children. Pregnancy and lactation.
Interaction
Concomitant treatment with cimetidine may inhibit the metabolism of mebendazole in the liver, resulting in increased plasma concentrations of the drug especially during prolonged treatment.
Food Interaction
- Take with or without food.
Vermol Disease Interaction
Elimination Route
Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.
Half Life
2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).
Elimination Route
In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.
Pregnancy & Breastfeeding use
Vermol should not be administered during pregnancy and in women thought to be pregnant. It is not known whether mebendazole or its metabolites are secreted in human breast milk. Thus Vermol should not be used during lactation unless the potential benefits are considered to outweigh the potential risk associated with treatment.
Contraindication
Vermol is contraindicated in pregnancy and in patients who have shown hypersensitivity to the product or any of its components.
Acute Overdose
Symptoms: Alopecia, reversible liver function disturbances, hepatitis, agranulocytosis, neutropenia, glomerulonephritis, abdominal cramps, nausea, vomiting and diarrhoea.
Management: Within the 1st hr after ingestion, gastric lavage may be performed. Activated charcoal may be given if considered appropriate.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Vermol
Vermol contains Mebendazole see full prescribing information from innovator Vermol Monograph, Vermol MSDS, Vermol FDA label
FAQ
What is Vermol used for?
Vermol is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, guinea worm infections, hydatid disease, and giardia, among others. Vermol also is used to treat: Common roundworms (ascariasis), Hookworms (ancylostomiasis, necatoriasis, uncinariasis).
How safe is Vermol?
Vermol generally safe. Taking an extra dose of Vermol by accident is unlikely to cause any harm.
How does Vermol work?
Vermol works by stopping the worms using sugar (glucose).
What are the common side effects of Vermol?
Common side effects of Vermol are include;
- diarrhea.
- stomach pain, discomfort, or swelling.
- nausea.
- vomiting.
- loss of appetite.
Is Vermol safe during pregnancy?
Vermol are well tolerated, with no adverse events in pregnant women and their fetuses when given after the first trimester of pregnancy.
Is Vermol safe during breastfeeding?
Vermol use during lactation is considered to be safe due to a low oral absorption and unlikely excretion in milk.
Can I drink alcohol with Vermol ?
Yes, you can drink alcohol with Vermol.
When should be best taken of Vermol?
Vermol is best taken with meals, especially fatty ones (eg, meals that include whole milk or ice cream). This helps to clear up the infection by helping your body absorb the medicine better.
How many time can I take Vermol daily?
Usually you need to take a dose 2 times a day for 3 days.
How long does Vermol take to work?
Vermol should start to work straight away but it may take several days to kill all the worms.
How long does Vermol stay in my system?
The apparent elimination half-life after an oral dose ranges from 3 to 6 hours in most patients.
How long can I take Vermol?
Vermol is usually taken as a single dose, but it can be taken for around 3 days for some infections. The most common side effect is stomach pain.
Who should not take Vermol?
Tell your doctor if you are pregnant or plan to become pregnant. Vermol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Vermol is not approved for use by anyone younger than 2 years old.
What happens if I overdose?
Seek emergency medical attention. Overdose symptoms may include upper stomach pain, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Can Vermol cause liver damage?
Vermol when given for prolonged periods in high doses has been associated with elevations in serum enzyme levels, and rare instances of acute, clinically apparent liver injury have been linked to its use.
