Vero-Bleomycin

Vero-Bleomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

Although the exact mechanism of action of bleomycin sulfate is unknown, available evidence indicates that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis.

Vero-Bleomycin is known to cause single, and to a lesser extent, double-stranded breaks in DNA. In in vitro and in vivo experiments, bleomycin has been shown to cause cell cycle arrest in G2 and in mitosis. When administered into the pleural cavity in the treatment of malignant pleural effusion, bleomycin sulfate acts as a sclerosing agent.

Vero-Bleomycin is an antibiotic which has been shown to have antitumor activity. Vero-Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Vero-Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Vero-Bleomycin (which has major effects in G2 and M phases).

Trade Name Vero-Bleomycin
Availability Prescription only
Generic Bleomycin
Bleomycin Other Names Bleocin, Bleomicin, Bleomicina, Bleomycin, Bleomycine, Bleomycinum
Related Drugs methotrexate, Keytruda, rituximab, pembrolizumab, Rituxan, doxorubicin, cisplatin, cyclophosphamide, Opdivo, nivolumab
Type
Formula C55H84N17O21S3
Weight Average: 1415.552
Monoisotopic: 1414.518979905
Protein binding

1%

Groups Approved, Investigational
Therapeutic Class Cytotoxic Chemotherapy
Manufacturer
Available Country Russia
Last Updated: September 19, 2023 at 7:00 am
Vero-Bleomycin
Vero-Bleomycin

Uses

Vero-Bleomycin is used for Malignant effusions, Lymphoma, Squamous cell or testicular tumours

Vero-Bleomycin is also used to associated treatment for these conditions: Cervical Cancers, Head and Neck Carcinoma, Intracranial Germ Cell Tumors, Lymphoma, Hodgkins, Malignant Pleural Effusions, Non-Hodgkin's Lymphoma (NHL), Ovarian Cancer, Penile Cancer, Pneumothorax, Testicular Cancer, Vulvar Cancers, Early Kaposi's sarcoma

How Vero-Bleomycin works

Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. As evident in in vitro studies, the DNA-cleaving actions of bleomycin is dependent on oxygen and metal ions. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.

Dosage

Vero-Bleomycin dosage

Squamous cell carcinoma:

  • Over 80 years: 15 mg per week (in a single or divided doses), total 100 mg
  • 70-79 years: 30 mg/week, total 150-200 mg
  • 60-69 years: 30-60 mg/week, total 200-300 mg
  • Under 60 years: 30-60 mg/wk, total 500 mg. All to be applied through slow intravenous or intravenous infusion.

Malignant lymphomas: 15 mg once or twice a week to a total dose of 225 mg.

CrCl 20-40 mcg/ml: Admin 50% of normal dose.

IM/SC: Add 1-5 mL or 2-10 mL of sterile water for inj, NaCl 0.9% inj, or bacteriostatic water for inj to the vial labelled as containing 15 IU or 30 IU of bleomycin, respectively, to provide a soln containing 3-15 IU/mL.

IV: Add 5 mL or 10 mL of NaCl 0.9% into the vial labelled as containing 15 IU or 30 IU of bleomycin, respectively, to provide a soln containing ≤3 IU/mL. Admin slowly over a 10-min period. Intrapleural: Dissolve 60 IU of bleomycin in 50-100 mL NaCl 0.9% inj.

Side Effects

Common side effects of Vero-Bleomycin Sulfate include injection site reactions (pain, redness, warmth, itching, or swelling), fever, chills, vomiting, loss of appetite, weight loss, darkening or discoloration of the skin, changes in fingernails or toenails, itching, or pain near your tumor.

Toxicity

Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Vero-Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.

Precaution

Caution should be taken in patient with severe heart disease, Renal impairment, Elderly & Pregnancy.

Interaction

Increased incidence and severity of lung toxicity with previous or concurrent radiotherapy to the chest. Combination with vinca alkaloids may result to a syndrome corresponding to morbus Raynaud, ischaemia which can lead to necrosis of peripheral parts of the body (fingers, toes, nose tip). May reduce the absorption of phenytoin. Increased risk of agranulocytosis with clozapine.

Food Interaction

No interactions found.

Elimination Route

Systemic absorption is approximately 45%.

Half Life

115 minutes

Elimination Route

It was reported that patients with moderately severe renal failure excreted less than 20% of the dose in the urine.

Pregnancy & Breastfeeding use

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk.

Contraindication

Acute pulmonary infection or greatly reduced lung function. Concomitant brentuximab, cisplatin or oxygen. Lactation.

Acute Overdose

Symptoms: Hypotension, fever, rapid pulse and general symptoms of shock.

Management: Symptomatic. In case of resp complications, treat with a corticosteroid and a broad-spectrum antibiotic.

Storage Condition

Store between 2-8°C. Protect from light.

Innovators Monograph

You find simplified version here Vero-Bleomycin

Vero-Bleomycin contains Bleomycin see full prescribing information from innovator Vero-Bleomycin Monograph, Vero-Bleomycin MSDS, Vero-Bleomycin FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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