Vetoryl

Vetoryl Uses, Dosage, Side Effects, Food Interaction and all others data.

Vetoryl is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.

Vetoryl blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Vetoryl reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.

Trade Name Vetoryl
Generic Trilostane
Trilostane Other Names Trilostane, Trilostano, Trilostanum
Type For animal use only
Formula C20H27NO3
Weight Average: 329.4333
Monoisotopic: 329.199093735
Groups Approved, Investigational, Vet approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Vetoryl
Vetoryl

Uses

Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

How Vetoryl works

Vetoryl produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

Toxicity

Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.

Food Interaction

No interactions found.

Half Life

8 hours.

Innovators Monograph

You find simplified version here Vetoryl

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http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32260
http://www.hmdb.ca/metabolites/HMDB0015240
http://www.genome.jp/dbget-bin/www_bget?drug:D01180
http://www.genome.jp/dbget-bin/www_bget?cpd:C12580
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656583
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507062
https://www.chemspider.com/Chemical-Structure.570949.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=38668
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=32260
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1200907
https://zinc.docking.org/substances/ZINC000100038546
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000148
http://www.pharmgkb.org/drug/PA164748507
https://en.wikipedia.org/wiki/Trilostane
*** Taking medicines without doctor's advice can cause long-term problems.
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