Vicalin
Vicalin Uses, Dosage, Side Effects, Food Interaction and all others data.
Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent . The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.
Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa . In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers . In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective . In a randomized clinical study consisting of patients with H. pylori-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of H. pylori .
Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach .
Neutralizes acid in the stomach .
| Trade Name | Vicalin |
| Generic | Acori Calami Rhizomata + Bismuth Subnitrate + Khellin + Magnesium Carbonate + Rhamni Frangulae Cortex + Rutoside + Sodium Hydrocarbonate |
| Type | |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Russia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Bismuth subnitrate is a medication used as an antacid.
Indicated for over-the-counter use as an antacid.
Magnesium carbonate is an antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Used as an over the counter antacid .
Vicalin is also used to associated treatment for these conditions: Acid indigestion, Bladder calculus, Heartburn, Kidney Stones, Upset stomach, Catheter irrigation
How Vicalin works
Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease . Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH .
Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach .
Toxicity
Reported oral dose range for moderate toxicity or possibly lethal toxicity in humans is 0.5-5 g/kg . Nephropathy, encephalopathy, osteoarthropathy, gingivitis, stomatitis and colitis have been attributed to bismuth toxicity in humans .
During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia .
Volume of Distribution
Bismuth has been shown to accumulate preferentially in the kidneys .
Vd for magnesium is 0.2-0.4L/kg . About 50% distributes to bone.
Elimination Route
Bismuth subnitrate may undergo minimal gastrointestinal absorption which may be potentiated with concomitant administration of sulfhydryl compounds when dissolved in citrate buffer solution . Approximately 0.2% of orally administered bismuth is absorbed systematically from the gastrointestinal tract with the peak plasma concentration typically occurring within 1 hour .
About 40-60% of magnesium is absorbed following oral administration . Percent absorption decreases as dose increases.
Half Life
The distribution half-life of bismuth is approximately 1 to 4 hours, and the elimination half-life is 5 to 11 days .
Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult .
Clearance
No pharmacokinetic data available.
Maximum magnesium clearance is directly proportional to creatinine clearance .
Elimination Route
Bismuth may undergo both urinary and faecal excretion, however the exact proportion contributed by each route is still unknown .
Primarily eliminated in urine .
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