Vicinium

Vicinium Uses, Dosage, Side Effects, Food Interaction and all others data.

VB4-845 is studied in the treatment of certain types of head and neck cancer. VB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. VB4-845 is a fusion protein containing humanized scFv specific for the epithelial cell adhesion molecule, Ep-CAM, a tumor cell-associated target highly expressed on carcinoma cells of epithelial origin and a truncated portion of Pseudomonas exotoxin A.

Trade Name Vicinium
Generic Oportuzumab monatox
Oportuzumab monatox Other Names Oportuzumab monatox
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Vicinium
Vicinium

Uses

Investigated for use/treatment in bladder cancer and head and neck cancer.

How Vicinium works

VB4-845 binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells). Also called anti-EpCAM-Pseudomonas-exotoxin fusion protein and Proxinium. It targets and kills Ep-CAM-positive tumors by apoptosis.

Innovators Monograph

You find simplified version here Vicinium

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