Vinorel Injection 10 mg/ml

Vinorel Injection 10 mg/ml Uses, Dosage, Side Effects, Food Interaction and all others data.

Vinorel Injection 10 mg/ml
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Vinorel Injection 10 mg/ml
Generic	Vinorelbine Tartrate
Weight	10 mg/ml
Type	Injection
Therapeutic Class	Cytotoxic Chemotherapy
Manufacturer	Beacon Pharmaceuticals PLC
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Vinorelbine is indicated: In combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) As a single agent, for the treatment of patients with metastatic NSCLC

Dosage

Vinorel Injection 10 mg/ml dosage

Intravenous (Adult): Cervical cancer:30 mg/m2 days 1 and 8 of a 21-day treatment cycle.Breast cancer, Ovarian cancer:25 mg/m2 dose every 7 days.Non-small cell lung cancer: As single agent: 30 mg/m2wkly as infusion over 20-30 minutes (after diluting in 125 ml normal saline or glucose 5%) or as slow bolus over 5-10 minutes (after diluting in 20-50 ml normal saline or glucose 5%). Delay subsequent doses if neutrophil count is <2000 cells/mm3until recovery. As combination therapy with cisplatin: 25-30 mg/m2every 7 days. Oral(Adult): Non-small cell lung cancer:60 mg/m2once wkly for 3 wk, may increase subsequently to 80 mg/m2once wkly. If neutrophil count is < 500 cells/mm3or between 500-1000 cells/mm3on 2 separate occasions, keep dose at 60 mg/m2for next 3 doses.

Side Effects

Neurotoxicity, peripheral paraesthesia, loss of deep tendon reflexes, abdominal pain, severe constipation, diarrhoea, alopecia, severe local irritation. Dose limiting granulocytopenia, leukopenia and anaemia. Intestinal obstruction, paralytic ileus, nausea, vomitinh, increased in LFT, chest pain, fatigue. Local pain and thrombophlebitis with repeated Inj.

Precaution

Hepatic impairment. Compromised bone marrow reserve due to prior irradiation or chemotherapy; recovering marrow function from the effects of previous chemotherapy. Prior radiation therapy; past history or pre-existing neuropathy. CBC with differentials to be monitored prior to admin of subsequent doses. Delay subsequent doses, if neutrophil count < 2000 cells/mm3. Each admin to be followed by at least 250 ml of normal saline to flush the vein. Avoid extravasation. If extravasation occurs, stop infusion immediately, and flush the vein with normal saline solution; admin the remaining solution in another vein. Do not father a child during and up to six mth after treatment and females of childbearing potential to use effective method of contraception during treatment and three mth thereafter. When admin orally, capsules must be swallowed whole with water and not chewed or sucked.

Interaction

Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.

Pregnancy & Breastfeeding use

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Contraindication

Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.

Special Warning

Hepatic Impairment:Intravenous: Cervical cancer: Dose adjustments may be needed. Breast cancer, Ovarian cancer: Dose adjustments may be needed. Non-small cell lung cancer: Massive liver metastases(>75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Oral: Massive liver metastases(>75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%.