Viomycine
Viomycine Uses, Dosage, Side Effects, Food Interaction and all others data.
Viomycine is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycine was derived from the actinomycete Streptomyces puniceus.
| Trade Name | Viomycine |
| Generic | Viomycin |
| Viomycin Other Names | Vinacetin A, Viomicina, Viomycin, Viomycine, Viomycinum |
| Type | |
| Formula | C25H43N13O10 |
| Weight | Average: 685.69 Monoisotopic: 685.325584661 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Viomycine is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
How Viomycine works
Viomycine binds to a site on the ribosome which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of this complexes suggest that the viomycin inhibits translocation by stabilizing the tRNA in the A site in the pretranslocation state. This inhibits protein synthesis.
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