Virenza (with Revolizer)
Virenza (with Revolizer) Uses, Dosage, Side Effects, Food Interaction and all others data.
A guanido-neuraminic acid that is used to inhibit neuraminidase.
Virenza (with Revolizer), an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days. Virenza (with Revolizer) has also been shown to significantly inhibit the human sialidases NEU3 and NEU2 in the micromolar range (Ki 3.7 +/-0.48 and 12.9+/-0.07 microM, respectively), which could account for some of the rare side effects of zanamivir.
| Trade Name | Virenza (with Revolizer) |
| Availability | Prescription only |
| Generic | Zanamivir |
| Zanamivir Other Names | Zanamivir |
| Related Drugs | amantadine, Tamiflu, oseltamivir, Fluzone, Vicks DayQuil Severe Cold & Flu, Xofluza, Coricidin HBP Cold & Flu, Afluria, Fluad, Relenza |
| Weight | 5mg |
| Type | Rotacap |
| Formula | C12H20N4O7 |
| Weight | Average: 332.3098 Monoisotopic: 332.133199014 |
| Protein binding | Zanamivir has limited plasma protein binding (<10%). |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Cipla Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Virenza (with Revolizer) is a neuraminidase inhibitor used to treat influenza A and B.
For the prevention and treatment of influenza A and B.
Virenza (with Revolizer) is also used to associated treatment for these conditions: Flu caused by Influenza
How Virenza (with Revolizer) works
The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others.
Food Interaction
No interactions found.Virenza (with Revolizer) Disease Interaction
Elimination Route
Absolute bioavailability is very low following oral administration (2%). Following oral inhalation, bioavailability is 4% to 17%.
Half Life
2.5-5.1 hours
Clearance
- 2.5 - 10.9 L/h [Following oral inhalation 10 mg]
- 5.3 L/h [Normal renal function receiving IV single dose of 4 mg or 2 mg]
- 2.7 L/h [Patients with mild and moderate renal impairement receiving IV single dose of 4 mg or 2 mg]
- 0.8 L/h [Patients with severe renal impairement receiving IV single dose of 4 mg or 2 mg]
Elimination Route
It is excreted unchanged in the urine with excretion of a single dose completed within 24 hours. Unabsorbed drug is excreted in the feces.Virenza (with Revolizer) is renally excreted as unchanged drug.
Innovators Monograph
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