Virolysis
Virolysis Uses, Dosage, Side Effects, Food Interaction and all others data.
An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Virolysis, a cyclic amine, is a synthetic antiviral drug and a derivate of adamantane, like a similar drug amantadine. Virolysis is inhibitory to the in vitro replication of influenza A virus isolates from each of the three antigenic subtypes (H1N1, H2H2 and H3N2) that have been isolated from man. Virolysis has little or no activity against influenza B virus. Virolysis does not appear to interfere with the immunogenicity of inactivated influenza A vaccine.
| Trade Name | Virolysis |
| Availability | Prescription only |
| Generic | Rimantadine |
| Rimantadine Other Names | alpha-Methyladamantanemethylamine, Rimantadina, Rimantadine, Rimantadinum |
| Related Drugs | amantadine, Tamiflu, oseltamivir, Fluzone, Xofluza, Afluria, Fluad, Flumadine |
| Type | |
| Formula | C12H21N |
| Weight | Average: 179.3018 Monoisotopic: 179.167399677 |
| Protein binding | Approximately 40% over typical plasma concentrations. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Egypt |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Virolysis is an RNA synthesis inhibitor used to prevent influenza A infection.
For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.
Virolysis is also used to associated treatment for these conditions: Influenza A Virus Infection
How Virolysis works
The mechanism of action of rimantadine is not fully understood. Virolysis appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. The protein coded by the M2 gene of influenza A may play an important role in rimantadine susceptibility.
Toxicity
Oral LD50 in rats is 640 mg/kg. Overdoses of a related rug, amantadine, have been reported with adverse reactions consisting of agitation, hallucinations, cardiac arrhythmia and death.
Food Interaction
No interactions found.Virolysis Disease Interaction
Moderate: liver disease, renal dysfunction, seizure disorders
Elimination Route
Well absorbed, with the tablet and syrup formulations being equally absorbed after oral administration.
Half Life
25 to 30 hours in young adults (22 to 44 years old). Approximately 32 hours in elderly (71 to 79 years old) and in patients with chronic liver disease. Approximately 13 to 38 hours in children (4 to 8 years old).
Elimination Route
Following oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug.
Innovators Monograph
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