Vita Men

Vita Men Uses, Dosage, Side Effects, Food Interaction and all others data.

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Vita Men (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K. The former, which is also known as phylloquinone, is synthesized by plants and can be found in such foods as spinach, broccoli, lettuce, and soybeans. The latter, sometimes alternatively referred to as menaquinone, is primarily produced by bacteria in the anterior part of the gut and the intestines. Vitamin K3, on the other hand, is one of the many manmade versions of vitamin K. Also called menadione, this yellowish, synthetic crystalline substance is converted into the active form of the K2 vitamin inside of the animal body. While a vitamin K deficiency can be dangerous, especially to infants that may easily suffer from extensive hemorrhaging, an overdose can be as equally detrimental. Newborns that are administered too great a dosage of vitamin K3 can suffer from kernicterus, a form of severe brain damage that may produce decreased movement, loss of appetite, seizures, deafness, mental retardation, and even death. This condition is associated with an abnormally high concentration of bilirubin, a bile pigment, in the tissues of the brain, which can be caused by the presence of K3. For this reason, K3 is less often utilized medically than it was in former times.

Trade Name Vita Men
Generic Menadione
Menadione Other Names Menadione, Vitamin K 3, Vitamin K3
Type
Formula C11H8O2
Weight Average: 172.18
Monoisotopic: 172.0524295
Groups Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country Germany
Last Updated: September 19, 2023 at 7:00 am
Vita Men
Vita Men

Uses

The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.

Vita Men is also used to associated treatment for these conditions: Factor II deficiency, Vitamin B12 Deficiency

How Vita Men works

Vita Men (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body. These proteins include the vitamin K-dependent coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor), X (Stuart factor), protein C, protein S, protein Zv and a growth-arrest-specific factor (Gas6). In contrast to the other vitamin K-dependent proteins in the blood coagulation cascade, protein C and protein S serve anticoagulant roles. The two vitamin K-dependent proteins found in bone are osteocalcin, also known as bone G1a (gamma-carboxyglutamate) protein or BGP, and the matrix G1a protein or MGP. Gamma-carboxylation is catalyzed by the vitamin K-dependent gamma-carboxylases. The reduced form of vitamin K, vitamin K hydroquinone, is the actual cofactor for the gamma-carboxylases. Proteins containing gamma-carboxyglutamate are called G1a proteins.

Toxicity

Vita Men (vitamin K3), which is not used as a nutritional supplemental form of vitamin K for humans, has been reported to cause adverse reactions, including hemolytic anemia. Large doses have also been reported to cause brain damage.

Elimination Route

Variable and ranges from 10% to 80%

Innovators Monograph

You find simplified version here Vita Men

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0000023
http://classyfire.wishartlab.com/tax_nodes/C0000153
http://classyfire.wishartlab.com/tax_nodes/C0000153
http://classyfire.wishartlab.com/tax_nodes/C0002495
http://classyfire.wishartlab.com/tax_nodes/C0003670
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28869
http://www.genome.jp/dbget-bin/www_bget?cpd:C05377
http://metacyc.org/META/new-image?type=COMPOUND&object=CPD-3766
http://www.hmdb.ca/metabolites/HMDB0001892
http://www.genome.jp/dbget-bin/www_bget?drug:D02335
http://www.genome.jp/dbget-bin/www_bget?cpd:C05377
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4055
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505447
https://www.chemspider.com/Chemical-Structure.3915.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24778
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6728
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=28869
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL590
https://zinc.docking.org/substances/ZINC000000001677
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC001501
http://www.pharmgkb.org/drug/PA450358
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2771
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/VK3
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0267.shtml
https://en.wikipedia.org/wiki/Menadione
*** Taking medicines without doctor's advice can cause long-term problems.
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