Xanelim

Xanelim Uses, Dosage, Side Effects, Food Interaction and all others data.

Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Xanelim has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.

Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.

Trade Name Xanelim
Availability Discontinued
Generic Efalizumab
Efalizumab Other Names anti-CD11a, antiCD11 alpha, Efalizumab
Related Drugs Humira, Otezla, Cosentyx, methotrexate, Enbrel, Remicade, Stelara, cyclosporine, infliximab
Type
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Xanelim
Xanelim

Uses

Xanelim is a monoclonal anti-CD11a antibody used to treat moderate to severe plaque psoriasis.

For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.

Xanelim is also used to associated treatment for these conditions: Moderate to Severe Chronic Plaque Psoriasis

How Xanelim works

Xanelim binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.

Elimination Route

Average efalizumab bioavailability following subcutaneous administration was estimated at 30 to 50%.

Half Life

5 days

Innovators Monograph

You find simplified version here Xanelim

*** Taking medicines without doctor's advice can cause long-term problems.
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