Xi Ai Ke Uses, Dosage, Side Effects and more
Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Xi Ai Ke is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).
Xi Ai Ke is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer. Xi Ai Ke causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Xi Ai Ke and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Xi Ai Ke has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.
| Attribute | Details |
|---|---|
| Trade Name | Xi Ai Ke |
| Generic | Vindesine |
| Vindesine Other Names | Desacetylvinblastine amide, Vindesina, Vindesine, Vindesinum |
| Type | |
| Formula | C43H55N5O7 |
| Weight | Average: 753.941 Monoisotopic: 753.410149131 |
| Protein binding | 65-75% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | China |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Xi Ai Ke is a vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).
For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
Xi Ai Ke is also used to associated treatment for these conditions: Acute Lymphocytic Leukemia (ALL), Blast Crisis, Melanoma, Malignant
How Xi Ai Ke works
Xi Ai Ke acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase.
Food Interaction
- Exercise caution with grapefruit products. Xi Ai Ke is metabolized by CYP3A4, and grapefruit inhibits CYP3A4 metabolism, which may increase vindesine serum levels.
- Exercise caution with St. John's Wort. Xi Ai Ke is metabolized by CYP3A4 and this herb induces CYP3A4 metabolism, which may reduce vindesine serum levels.
Half Life
24 hours.
