Yi You Li An
Yi You Li An Uses, Dosage, Side Effects, Food Interaction and all others data.
Yi You Li An, a nonsulfonylurea hypoglycaemic agent which stimulates insulin release from the pancreatic β-cells by blocking ATP-dependent K channels, depolarising the membrane and facilitating Ca entry through Ca channels. This action depends on the amount of existing glucose levels.
Insulin secretion by pancreatic β cells is partly controlled by cellular membrane potential. Membrane potential is regulated through an inverse relationship between the activity of cell membrane ATP-sensitive potassium channels (ABCC8) and extracellular glucose concentrations. Extracellular glucose enters the cell via GLUT2 (SLC2A2) transporters. Once inside the cell, glucose is metabolized to produce ATP. High concentrations of ATP inhibit ATP-sensitive potassium channels causing membrane depolarization. When extracellular glucose concentrations are low, ATP-sensitive potassium channels open causing membrane repolarization. High glucose concentrations cause ATP-sensitive potassium channels to close resulting in membrane depolarization and opening of L-type calcium channels. The influx of calcium ions stimulates calcium-dependent exocytosis of insulin granules. Yi You Li An increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner.
Trade Name | Yi You Li An |
Availability | Prescription only |
Generic | Nateglinide |
Nateglinide Other Names | Nateglinida, Nateglinide, Natéglinide, Nateglinidum |
Related Drugs | Farxiga, metformin, Trulicity, Lantus, Victoza, Tresiba, Levemir |
Type | |
Formula | C19H27NO3 |
Weight | Average: 317.429 Monoisotopic: 317.199093733 |
Protein binding | 98% bound to serum proteins, primarily serum albumin and to a lesser extent α1 acid glycoprotein |
Groups | Approved, Investigational |
Therapeutic Class | Meglitinide Analogues |
Manufacturer | |
Available Country | China |
Last Updated: | September 19, 2023 at 7:00 am |
![Yi You Li An Yi You Li An](https://www.medicinesfaq.com/media/png/yi-you-li-an.png)
Uses
Yi You Li An is used for an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Yi You Li An is also used to associated treatment for these conditions: Type 2 Diabetes Mellitus
How Yi You Li An works
Yi You Li An activity is dependent on the presence functioning β cells and glucose. In contrast to sulfonylurea insulin secretatogogues, nateglinide has no effect on insulin release in the absence of glucose. Rather, it potentiates the effect of extracellular glucose on ATP-sensitive potassium channel and has little effect on insulin levels between meals and overnight. As such, nateglinide is more effective at reducing postprandial blood glucose levels than fasting blood glucose levels and requires a longer duration of therapy (approximately one month) before decreases in fasting blood glucose are observed. The insulinotropic effects of nateglinide are highest at intermediate glucose levels (3 to 10 mmol/L) and it does not increase insulin release already stimulated by high glucose concentrations (greater than 15 mmol/L). Yi You Li An appears to be selective for pancreatic β cells and does not appear to affect skeletal or cardiac muscle or thyroid tissue.
Dosage
Yi You Li An dosage
Initial dose: 120 mg orally 3 times a day before meals
Maintenance dose: 60 to 120 mg orally 3 times a day before meals
For patients who are near goal HbA1c when therapy is initiated, therapy should be initiated at 60 mg orally 3 times. May be used as monotherapy, or in combination with metformin or a thiazolidinedione. As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Take orally 1 to 30 minutes before a meal. Patients who skip a meal should be instructed to skip the dose for that meal
Side Effects
Hypoglycaemia, upper respiratory tract infection, back pain, flu-like symptoms, dizziness, arthropathy, diarrhoea, accidental trauma, bronchitis, cough.
Toxicity
An overdose may result in an exaggerated glucose-lowering effect with the development of hypoglycemic symptoms.
Precaution
Patient with adrenal and/or pituitary impairment. Severe renal and moderate to severe hepatic impairment. Pregnancy and lactation.
Interaction
CYP2C9 and CYP3A4 inhibitors or inducers may alter metabolism of nateglinide. Increased hypoglycaemic effects with MAOIs, nonselective β-adrenergic blockers, NSAIDs, salicylates. Decreased hypoglycaemic effects with corticosteroids, sympathomimetic agents, thiazide diuretics, thyroid hormones.
Food Interaction
- Take with food. Take up to 30 minutes before meals.
[Moderate] GENERALLY AVOID: Alcohol may cause hypoglycemia or hyperglycemia in patients with diabetes.
Hypoglycemia most frequently occurs during acute consumption of alcohol.
Even modest amounts can lower blood sugar significantly, especially when the alcohol is ingested on an empty stomach or following exercise.
The mechanism involves inhibition of both gluconeogenesis as well as the counter-regulatory response to hypoglycemia.
Episodes of hypoglycemia may last for 8 to 12 hours after ethanol ingestion.
By contrast, chronic alcohol abuse can cause impaired glucose tolerance and hyperglycemia.
Moderate alcohol consumption generally does not affect blood glucose levels in patients with well controlled diabetes.
A disulfiram-like reaction (e.g., flushing, headache, and nausea) to alcohol has been reported frequently with the use of chlorpropamide and very rarely with other sulfonylureas.
MANAGEMENT: Patients with diabetes should avoid consuming alcohol if their blood glucose is not well controlled, or if they have hypertriglyceridemia, neuropathy, or pancreatitis.
Patients with well controlled diabetes should limit their alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with their normal meal plan.
Alcohol should not be consumed on an empty stomach or following exercise.
Yi You Li An Drug Interaction
Moderate: aspirin, aspirin, sitagliptin, metoprolol, metoprolol, levothyroxine, linagliptin, liraglutideUnknown: rosuvastatin, omega-3 polyunsaturated fatty acids, insulin glargine, insulin glargine, atorvastatin, pregabalin, esomeprazole, clopidogrel, cyanocobalamin, ascorbic acid, ergocalciferol, cholecalciferol
Yi You Li An Disease Interaction
Major: type I diabetes, cardiovascular riskModerate: hypoglycemia, liver disease
Volume of Distribution
10 liters in healthy subjects
Elimination Route
Rapidly absorbed following oral administration prior to a meal, absolute bioavailability is estimated to be approximately 73%. Peak plasma concentrations generally occur within 1 hour of oral administration. Onset of action is <20 minutes and the duration of action is approximately 4 hours.
Half Life
1.5 hours
Elimination Route
Urine (83%) and feces (10%)
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
IDDM, diabetic ketoacidosis.
Special Warning
Renal Dose Adjustments: No adjustment recommended
Mild hepatic impairment: No adjustment recommended
Moderate to severe hepatic impairment: Use caution
Elderly: No adjustment recommended; however, some individuals may have a greater sensitivity to therapy. Insulin therapy may be temporarily needed in times of fever, infection, trauma, or surgery.
Younger than 18 years: Safety and efficacy have not been established in patients younger than 18 years.
Acute Overdose
Symptoms: Hypoglycaemia.
Management: Use IV glucose in severe reaction.
Storage Condition
Store at 25° C.
Innovators Monograph
You find simplified version here Yi You Li An
Yi You Li An contains Nateglinide see full prescribing information from innovator Yi You Li An Monograph, Yi You Li An MSDS, Yi You Li An FDA label