Yohimbe Bark

Yohimbe Bark Uses, Dosage, Side Effects, Food Interaction and all others data.

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbe Bark has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Yohimbe Bark is an indolalkylamine alkaloid with chemical similarity to reserpine. Yohimbe Bark blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of short duration. Yohimbe Bark's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) activity. It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both. Yohimbe Bark exerts a stimulating action on the mood and may increase anxiety. Such actions have not been adequately studied or related to dosage although they appear to require high doses of the drug. Yohimbe Bark has a mild anti-diuretic action, probably via stimulation of hypothalmic center and release of posterior pituitary hormone. Reportedly Yohimbe Bark exerts no significant influence on cardiac stimulation and other effects mediated by (beta)-adrenergic receptors. Its effect on blood pressure, if any, would be to lower it; however, no adequate studies are at hand to quantitate this effect in terms of Yohimbe Bark dosage.

Yohimbe Bark
Uses
Dosage
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Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Trade Name	Yohimbe Bark
Availability	Prescription only
Generic	Yohimbine
Yohimbine Other Names	Johimbin, Quebrachin, Yohimbic acid methyl ester, Yohimbin, Yohimbine, Yohimbinum
Related Drugs	sildenafil, tadalafil, Viagra, Cialis, alprostadil, Levitra
Type
Formula	C₂₁H₂₆N₂O₃
Weight	Average: 354.4427 Monoisotopic: 354.194342708
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country	Egypt
Last Updated:	September 19, 2023 at 7:00 am

Uses

Yohimbe Bark is an alpha-2-adrenergic blocker and sympatholytic found in supplements used to.

Indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins.

How Yohimbe Bark works

Yohimbe Bark is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbe Bark-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.