Z-B
Z-B Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Z-B |
| Generic | Zinc Sulfate + Boric Acid |
| Weight | (0.50gm+4gm)/1000cc |
| Type | Eye Drops |
| Therapeutic Class | Ophthalmic Non-Steroid drugs |
| Manufacturer | Reman Drug Laboratories Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Allergic blepharitis, Allergic conjunctivitis, Blepharitis
Z-B is also used to associated treatment for these conditions: Acne, Asthenopia, Ocular Irritation, Skin Mycoses, Eye discomfort, Skin disinfection, Irrigation of the ocular surface therapyDry Eyes, Local itching, Localized pain, Localized swelling, Nutritional supplementation
How Z-B works
Information regarding the mechanism of action of boric acid in mediating its antibacterial or antifungal actions is limited. Boric acid inhibits biofilm formation and hyphal transformation of Candida albicans, which are critical virulence factors . In addition, arrest of fungal growth was observed with the treatment of boric acid .
Zinc inhibits cAMP-induced, chloride-dependent fluid secretion by inhibiting basolateral potassium (K) channels, in in-vitro studies with rat ileum. This study has also shown the specificity of Zn to cAMP-activated K channels, because zinc did not block the calcium (Ca)-mediated K channels. As this study was not performed in Zn-deficient animals, it provides evidence that Zn is probably effective in the absence of Zn deficiency. Zinc also improves the absorption of water and electrolytes, improves regeneration of the intestinal epithelium, increases the levels of brush border enzymes, and enhances the immune response, allowing for a better clearance of the pathogens.
Dosage
Z-B dosage
1-2 drops 2 to 3 times daily.
Toxicity
Acute oral LD50 is 2660 mg/kg in rat . Individuals are likely to be exposed to boric acid from industrial manufacturing or processing. Local tissue injury from boric acid exposure is likely due to caustic effects. Systemic effects from boric acid poisoning usually occur from multiple exposures over a period of days and involve gastrointestinal, dermal, CNS, and renal manifestations. Gastrointestinal toxicity include persistent nausea, vomiting, diarrhea, epigastric pain, hematemesis, and blue-green discoloration of the feces and vomit . Following the onset of GI symptoms, a characteristic intense generalized erythroderma follows . Management of mild to moderate toxicity should be supportive. In case of severe toxicity, dialysis may be required in addition to supportive treatment.
Human : TDLo ( Oral) 45mg/kg/7D-C : Normocytic anemia, pulse rate increase without fall inBP Human: TDLo (oral) 106mg/kg : Hypermotylity, diarrhea Mouse ; LD50 Oral : 245mg/kg Mouse : LD50 : subcutaneous : 781mg/kg
Volume of Distribution
Volume of distribution ranges from 0.17 to 0.5 L/kg in humans, where large amounts of boric acid are localized in brain, liver, and kidney .
After absorption zinc is bound to protein metallothionein in the intestines. Zinc is widely distributed throughout the body. It is primarily stored in RBCs, WBCs, muscles, bones, Skin, Kidneys, Liver, Pancreas, retina, and prostate.
Elimination Route
Boric acid is well absorbed from the gastrointestinal tract, open wounds, and serous cavities but displays limited absorption in intact skin . Following intraperitoneal injection in mice, the peak concentration was reached in about 1.0-1.5 hr in the brain whereas the value was 0.5 hr in other tissues .
Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum. The amount absorbed is dependent on the bioavailability from food. Zinc is the most bioavailable from red meat and oysters. Phytates may impair absorption by chelation and formation of insoluble complexes at an alkaline pH. After absorption, zinc is bound in the intestine to the protein metallothionein. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc.
Half Life
According to human cases of poisoning, the elimination half-life of boric acid ranges from 13 to 24 hours .
3 hours
Clearance
A case report of acute boric acid poisoning following oral ingestion of 21 g of boric acid presents the total body clearance of 0.99 L/h before hemodialysis .
Elimination Route
Regardless the route of administration, boric acid predominantly undergoes rapid renal excretion of >90% of total administered dose as unchanged form. Small amounts are also excreted into sweat, saliva, and feces. Following administration as ointment, urinary excretion of boric acid accounted for only 1% of the administered dose .
Primarily fecal (approximately 90%); to a lesser extent in the urine and in perspiration.
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FAQ
What Z-B is used for?
Z-B is used to treat zinc deficiency and to prevent the condition in those at high risk.Z-B is used medically as a dietary supplement.
What are the side effects of Z-B?
- severe burning or stinging of your eyes;
- severe eye pain;
- vision changes that last for several hours after use; or.
- if your eye condition does not improve or if it gets worse after using boric acid.
Who should not take Z-B?
You should not use this medication if you are allergic to Z-B.
Avoid using this medication if you have any open wound or other skin injury around your eyes.
Z-B is a weak antibiotic and should not be used to treat any type of infection without the advice of a doctor. There are many other, more effective antibiotics available.
Is Z-B safe?
Z-B is likely safe when used in amounts no greater than 40 mg daily. It is possibly safe when taken in larger doses, especially when used only for a short period of time.
Is it safe to take Z-B everyday?
The National Institutes of Health considers 40 mg of Z-B a day to be the upper limit dose for adults and 4 mg of Z-B a day for infants under age 6 months.
Is Z-B safe during pregnancy?
Safety for use in pregnancy has not been established. The risk of fetal harm if used during pregnancy is remote. A dietary intake of 11 mg of zinc per day (19 to 50 years of age) and 12 mg per day (14 to 18 years of age) is recommended during pregnancy.
Is Z-B safe during breastfeeding?
Yes, Z-B is safe to take while breastfeeding. Amount: 12 mg is the daily recommended amount for breastfeeding moms. The NIH says the tolerable upper limit for adults is 40 mg.
Can I take Z-B while drinking alcohol?
During perfusion with a Z-B-containing medium (with and without alcohol), alcohol was found to have no effect on net Z-B uptake from the lumen of the intestine.
When should I take Z-B ?
Take this medication by mouth as directed by your doctor or on the package. Take this medication 1 hour before or 2 hours after meals. May be taken with food if it upsets your stomach.
Is Z-B good for skin?
Z-B is an important nutrient for healthy skin. Z-B has anti-inflammatory properties and is useful for inflammatory skin diseases, such as acne, rosacea, eczema, and ulcers.
Can Z-B cause blood clots?
Z-B is released from cells called platelets that control blood clotting, and scientists have found unwanted blood clots can form when Z-B levels in the blood are faulty.
Can Z-B help my lose weight?
Z-B daily administration of 30 mg Z-B gluconate for 1 month reduced body weight, BMI and waist circumferences in the healthy obese adults. It is documented that body weight management requires restricting energy intake, and increasing energy expenditure.
What are the benefits of taking Z-B?
Here are seven potential benefits that have been linked to zinc supplements.
- Boosts the Immune System. ...
- Decreases Risk of Preterm Birth. ...
- Supports Childhood Growth. ...
- Manages Blood Sugar. ...
- Slows the Progression of Macular Degeneration. ...
- Clears Up Acne. ...
- Promotes a Healthy Heart and Blood Vessels.
Is Z-B bad for the kidneys?
New research on kidney stone formation reveals that Z-B levels may contribute to kidney stone formation, a common urinary condition that can cause excruciating pain. The research found that Z-B may be the core by which stone formation starts.
When should I take Z-B ?
Z-B may be best taken in the evening and with food, which aids in their absorption because of their calming effects.Z-B is best taken 1 hour before or 2 hours after meals, according to the Mayo Clinic, but may lead to gastrointestinal distress if taken on an empty stomach.
Does Z-B make me sleepy?
Z-B is one of the three minerals that have a sedative effect on the nervous system and is also thought to help mental recovery post-stress.
Can I take Z-B with other vitamins?
Don't take Z-B at the same time as iron or calcium supplements. A strong relationship exists between Z-B and copper. Too much of one can cause a deficiency in the other. If you take Z-B, including Z-B in a multivitamin, you should also take copper.
Can Z-B give you energy?
The good news is that Z-B can help with fatigue issues and give someone more energy throughout the day.
How does Z-B help the immune system?
Z-B is found in cells throughout the body. It helps the immune system fight off invading bacteria and viruses. The body also needs Z-B to make proteins and DNA, the genetic material in all cells.
