Zastidine
Zastidine Uses, Dosage, Side Effects, Food Interaction and all others data.
Zastidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Zastidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Trade Name | Zastidine |
Availability | Rx and/or OTC |
Generic | Nizatidine |
Nizatidine Other Names | Nizatidina, Nizatidine, Nizatidinum |
Related Drugs | omeprazole, famotidine, pantoprazole, Nexium, Pepcid, Protonix, esomeprazole, sucralfate, Prilosec, ranitidine |
Type | |
Formula | C12H21N5O2S2 |
Weight | Average: 331.45 Monoisotopic: 331.113667284 |
Protein binding | 35% |
Groups | Approved |
Therapeutic Class | H2 receptor antagonist |
Manufacturer | |
Available Country | South Korea |
Last Updated: | September 19, 2023 at 7:00 am |
![Zastidine Zastidine](https://www.medicinesfaq.com/media/png/zastidine.png)
Uses
Zastidine is used for up to 8 weeks for the treatment of active duodenal ulcer. In most patients, the ulcer will heal within 4 weeks.
Zastidine is used for maintenance therapy for duodenalulcer patients, at a reduced dosage of 150 mg h.s. after healing of an active duodenal ulcer. The consequences of continuous therapy with Zastidine for longer than 1 year are not known.
Zastidine is used for up to 12 weeks for the treatment of endoscopically diagnosed esophagitis, including erosive and ulcerative esophagitis, and associated heartburn due to GERD.
Zastidine is used for up to 8 weeks for the treatment of active benign gastric ulcer. Before initiating therapy, care should be taken to exclude the possibility of malignant gastric ulceration.
Zastidine is also used to associated treatment for these conditions: Duodenal Ulcer, Esophagitis, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Helicobacter Pylori Infection, Peptic Ulcer Disease, Stress Ulcers
How Zastidine works
Zastidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.
Dosage
Zastidine dosage
Active Duodenal Ulcer: The recommended oral dosage for adults is 300 mg once daily at bedtime. An alternative dosage regimen is 150 mg twice daily.
Maintenance of Healed Duodenal Ulcer: The recommended oral dosage for adults is 150 mg once daily at bedtime.
Gastroesophageal RefluxDisease: The recommended oral dosage in adults for the treatment of erosions, ulcerations, and associated heartburn is 150mg twice daily.
Active Benign Gastric Ulcer: The recommended oral dosage is 300 mg given either as 150 mg twice daily or 300 mg once daily at bedtime. Prior to treatment, care should be taken to exclude the possibility of malignant gastric ulceration.
Side Effects
Headache, dizziness, insomnia, abnormal dreams, somnolence, asthenia, anxiety, excessive sweating, diarrhoea, nausea and/or vomiting, abdominal pain/discomfort, constipation, flatulence, dyspepsia, dry mouth, anorexia, tooth disorder, urticaria, rash, pruritus, exfoliative dermatitis, anaemia, rhinitis, pharyngitis, sinusitis, reversible hepatocellular injury, diaphoresis, myalgia, fever. Rarely, asymptomatic ventricular tachycardia, thrombocytopenic purpura, decreased libido, gynaecomastia, reversible cholestatic or mixed cholestatic-hepatocellular injury with jaundice.
Toxicity
Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
Precaution
Possibility of malignancy should be excluded prior to therapy as the drug may mask symptoms and delay diagnosis of gastric malignancy. Increased risk of community-acquired pneumonia. Renal impairment. Pregnancy and lactation.
Interaction
No interactions have been observed between Zastidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. Zastidine does not inhibit the cytochrome P-450-linked drug-metabolizing enzyme system; therefore, drug interactions mediated by inhibition of hepatic metabolism are not expected to occur. In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.
Food Interaction
- Avoid alcohol.
- Limit caffeine intake.
- Take with or without food. The absorption is unaffected by food.
Zastidine Drug Interaction
Minor: duloxetineUnknown: aspirin, celecoxib, rosuvastatin, escitalopram, atorvastatin, pregabalin, esomeprazole, acetaminophen, clopidogrel, quetiapine, montelukast, levothyroxine, acetaminophen, ascorbic acid, cholecalciferol, alprazolam, ranitidine, ondansetron, cetirizine
Zastidine Disease Interaction
Volume of Distribution
- 0.8 to 1.5 L/kg
Elimination Route
Rapid (bioavailability of nizatidine exceeds 70%)
Half Life
1-2 hours
Clearance
- 40-60 L/h
- 7 – 14 L/h [functionally anephric patients]
Pregnancy & Breastfeeding use
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Contraindication
Zastidine is contraindicated in patients with known hypersensitivity to the drug. Because cross sensitivity in this class of compounds has been observed, H2-receptor antagonists, including Zastidine , should not be administered to patients with a history of hypersensitivity to other H2-receptor antagonists.
Special Warning
Dosage Adjustment for Patients With Moderate to Severe Renal Insufficiency-Active Duodenal Ulcer, GERD and Benign Gastric Ulcer:
- CrCl 20-50 ml/min: 150 mg daily
- CrCl <20 ml/min: 150 mg every other day
Maintenance Therapy:
- CrCl 20-50 ml/min: 150 mg every other day
- CrCl <20 mL/min: 150 mg every 3 days
Some elderly patients may have creatinine clearances of less than 50 ml/min, and, based on pharmacokinetic data in patients with renal impairment, the dose for such patients should be reduced accordingly. The clinical effects of this dosage reduction in patients with renal failure have not been evaluated.
Acute Overdose
Symptoms: Lacrimation, salivation, emesis, miosis, and diarrhoea.
Management: Symptomatic and supportive treatment. Activated charcoal, emesis or lavage may reduce absorption.
Storage Condition
Store at 25°C
Innovators Monograph
You find simplified version here Zastidine
Zastidine contains Nizatidine see full prescribing information from innovator Zastidine Monograph, Zastidine MSDS, Zastidine FDA label