Zavedos, Poeder Voor Oplossing Voor Injectie
Zavedos, Poeder Voor Oplossing Voor Injectie Uses, Dosage, Side Effects, Food Interaction and all others data.
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Zavedos, Poeder Voor Oplossing Voor Injectie is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Zavedos, Poeder Voor Oplossing Voor Injectie may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Zavedos, Poeder Voor Oplossing Voor Injectie possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
| Trade Name | Zavedos, Poeder Voor Oplossing Voor Injectie |
| Availability | Prescription only |
| Generic | Idarubicin |
| Idarubicin Other Names | 4-Demethoxydaunorubicin, Idarubicin, Idarubicina, Idarubicine, Idarubicinum |
| Related Drugs | Venclexta, prednisone, methotrexate, dexamethasone, triamcinolone, Decadron, Keytruda, hydroxyurea, pembrolizumab, vincristine |
| Type | |
| Formula | C26H27NO9 |
| Weight | Average: 497.4939 Monoisotopic: 497.168581467 |
| Protein binding | 97% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Netherlands |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zavedos, Poeder Voor Oplossing Voor Injectie is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.
For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
Zavedos, Poeder Voor Oplossing Voor Injectie is also used to associated treatment for these conditions: Acute Myeloid Leukemia (AML)
How Zavedos, Poeder Voor Oplossing Voor Injectie works
Zavedos, Poeder Voor Oplossing Voor Injectie has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Zavedos, Poeder Voor Oplossing Voor Injectie forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Food Interaction
No interactions found.Zavedos, Poeder Voor Oplossing Voor Injectie Drug Interaction
Moderate: cytarabine, cytarabine, filgrastim, filgrastimMinor: sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprimUnknown: diphenhydramine, diphenhydramine, meperidine, meperidine, epoetin alfa, epoetin alfa, enoxaparin, enoxaparin, gemtuzumab, gemtuzumab, acetaminophen, acetaminophen, azacitidine, azacitidine
Zavedos, Poeder Voor Oplossing Voor Injectie Disease Interaction
Major: infections, heart disease, hepatic dysfunction, myelosuppression, renal dysfunctionModerate: hyperuricemia
Half Life
22 hours
Elimination Route
The drug is eliminated predominately by biliary and to a lesser extent by renal excretion, mostly in the form of idarubicinol.
Innovators Monograph
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