Zeftera
Zeftera Uses, Dosage, Side Effects, Food Interaction and all others data.
Zeftera is a cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus. It was discovered by Basilea Pharmaceutica and is being developed by Johnson & Johnson Pharmaceutical Research and Development. Zeftera is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia.
Zeftera, a cephalosporin antibiotic, is active against methicillin-resistant Staphylococcus aureus.
Trade Name | Zeftera |
Generic | Ceftobiprole |
Ceftobiprole Other Names | Ceftobiprol, Ceftobiprole |
Type | |
Formula | C20H22N8O6S2 |
Weight | Average: 534.57 Monoisotopic: 534.110372808 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
![Zeftera Zeftera](https://www.medicinesfaq.com/media/png/zeftera.png)
Uses
Zeftera is a cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria.
For the treatment of serious bacterial infections in hospitalised patients.
Zeftera is also used to associated treatment for these conditions: Community Acquired Pneumonia (CAP), Nosocomial Pneumonia
How Zeftera works
Cephalosporins, such as ceftobiprole, are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam antibiotics mimic this site and competitively inhibit PBP crosslinking of peptidoglycan.
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here Zeftera