Zeneril
Zeneril Uses, Dosage, Side Effects, Food Interaction and all others data.
Zeneril is a piperidine phenothiazine which blocks postsynaptic mesolimbic dopaminergic receptors in the brain. It exhibits a strong α-adrenergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones.
Zeneril is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Zeneril has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Trade Name | Zeneril |
Availability | Prescription only |
Generic | Thioridazine |
Thioridazine Other Names | Thioridazin, Thioridazine, Thioridazinum, Tioridazina |
Related Drugs | quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone |
Type | Tablet |
Formula | C21H26N2S2 |
Weight | Average: 370.575 Monoisotopic: 370.153740222 |
Protein binding | 95% |
Groups | Approved, Withdrawn |
Therapeutic Class | Phenothiazine drugs, Phenothiazine related drugs |
Manufacturer | Reliance Formulation Pvt Ltd |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zeneril is used for the management of schizophrenic patients who fail to respond adequately to treatment with other antipsychotic drugs. Due to the risk of significant, potentially life-threatening, proarrhythmic effects with thioridazine treatment, thioridazine should be used only in patients who have failed to respond adequately to treatment with appropriate courses of other antipsychotic drugs, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs. Consequently, before initiating treatment with thioridazine, it is strongly recommended that a patient be given at least 2 trials, each with a different antipsychotic drug product, at an adequate dose, and for an adequate duration.
However, the prescriber should be aware that thioridazine has not been systematically evaluated in controlled trials in treatment refractory schizophrenic patients and its efficacy in such patients is unknown.
Zeneril is also used to associated treatment for these conditions: Psychosis, Schizophrenia
How Zeneril works
Zeneril blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Dosage
Zeneril dosage
Since thioridazine is associated with a dose-related prolongation of the QTc interval, which is a potentially life-threatening event, its use should be reserved for schizophrenic patients who fail to respond adequately to treatment with other antipsychotic drugs. Dosage must be individualized and the smallest effective dosage should be determined for each patient
Adults: The usual starting dose for adult schizophrenic patients is 50 to 100 mg three times a day, with a gradual increment to a maximum of 800 mg daily if necessary. Once effective control of symptoms has been achieved, the dosage may be reduced gradually to determine the minimum maintenance dose. The total daily dosage ranges from 200 to 800 mg, divided into two to four doses.
Pediatric: For pediatric patients with schizophrenia who are unresponsive to other agents, the recommended initial dose is 0.5 mg/kg/day given in divided doses. Dosage may be increased gradually until optimumtherapeuticeffect is obtained or the maximum dose of 3 mg/kg/day has been reached.
Side Effects
Tardive dyskinesia; leucopenia, neutropenia, agranulocytosis; drowsiness, pseudoparkinsonism and other extrapyramidal symptoms; dry mouth, blurred vision, constipation, nausea, vomiting, diarrhoea, nasal stuffiness, pallor; galactorrhoea, breast engorgement, amenorrhoea, inhibition of ejaculation, peripheral oedema; dermatitis, skin eruptions. Rarely, nocturnal confusion, hyperactivity, lethargy, psychotic reactions, restlessness, headache, photosensitivity, parotid swelling.
Toxicity
LD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
Precaution
Patient with severe CV disease, narrow-angle glaucoma, Parkinson's disease, seizure disorder. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly with dementia-related psychosis. Pregnancy and lactation.
Interaction
May potentiate the effects of CNS depressants (e.g. anaesth, barbiturates, narcotics, opiates, other psychoactive drugs).
Food Interaction
- Avoid alcohol. Ingesting alcohol may potentiate the CNS depressant actions of thioridazine.
Zeneril Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Zeneril Drug Interaction
Major: citalopram, escitalopram, fluoxetine, risperidone, quetiapine, ondansetronModerate: aripiprazole, amphetamine / dextroamphetamine, zolpidem, divalproex sodium, ginkgo, gabapentin, alprazolamUnknown: calcium / vitamin d, atorvastatin, acetaminophen, levothyroxine, acetaminophen, cyanocobalamin, cholecalciferol
Zeneril Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injury, QT interval prolongationModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Elimination Route
60%
Half Life
21-25 hours
Pregnancy & Breastfeeding use
Pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Patients with reduced levels of CYP2D6 isoenzyme, congenital long QT syndrome or history of cardiac arrhythmias; severe CNS depression or comatose states of any cause; hypertensive or hypotensive heart disease of extreme degree. Concomitant use with drugs that prolong QTc interval, CYP2D6 isoenzyme inhibitors and drugs which reduce thioridazine clearance by other mechanisms.
Special Warning
Renal Impairment: Lower initial doses and more gradual dosage increase.
Hepatic Impairment: Lower initial doses and more gradual dosage increase.
Acute Overdose
Symptoms: Cardiotoxicity (e.g. prolongation of QT interval and QRS complex).
Management: Symptomatic and supportive treatment with CV (e.g. ECG) monitoring. Establish a patent airway and ensure adequate oxygenation and ventilation. Employ gastric lavage and administer repeated doses of activated charcoal. May include ventricular pacing, defibrillation, admin of IV Mg sulfate, lidocaine, phenytoin or isoproterenol, correction of electrolyte abnormalities and/or acid-base balance to manage arrhythmias. Administer lidocaine with caution as it may increase the risk of developing seizures.
Storage Condition
Store between 15-30° C. Protect from light.
Innovators Monograph
You find simplified version here Zeneril
FAQ
What is Zeneril used for?
Zeneril is used to treat certain mental/mood disorders . This medication helps you to think more clearly, feel less nervous, and take part in everyday life. It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others.
How safe Zeneril is?
Zeneril can cause a serious type of irregular heartbeat that may cause sudden death. There are other medications that can be used to treat your condition that are less likely to cause this life-threatening side effect.
What are the common side effects of Zeneril?
Zeneril may cause side effects are include.
- drowsiness
- blurred vision
- dry mouth
- nausea
- vomiting
- diarrhea
- constipation
- changes in appetite
- weight gain
- stuffed nose
- pale skin
- darkening of the skin or eyes
- swelling of the arms, hands, feet, ankles, or lower legs
- blank facial expression
- shuffling walk
- unusual, slowed, or uncontrollable movements of any part of the body
- restlessness
- unusual dreams
- breast milk production
- breast enlargement
- missed menstrual periods
- decreased sexual ability in men
- difficulty urinating
What type of medication is Zeneril?
Zeneril belongs to a class of drugs called Antipsychotics, Phenothiazine.
Does Zeneril affect my heart?
Zeneril can cause a serious heart problem, especially if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
How long does Zeneril last?
The duration of activity following intramuscular administration may last up to 12 hours.
Is Zeneril safe during pregnancy?
Not formally assigned to a pregnancy category.Neonates exposed during the third trimester are at risk of developing severe and/or prolonged side effects.
Is Zeneril safe during breastfeeding?
The manufacturer makes no recommendation regarding use during breastfeeding.
Can I drink alcohol with Zeneril?
It is recommended that you avoid Alcoholic drinks while you are taking this medication. Alcohol can increase the risk of side effects, such as drowsiness and dizziness.
Can I drive after taking Zeneril?
Do not drive, use machinery, or do other activity requiring full alertness after using Zeneril.
Does Zeneril cause weight gain?
Zeneril produced a mean weight gain and loxapine a mean weight loss after 12 and 36 weeks of treatment.
Can I take Zeneril long time?
long-term use of Zeneril can cause a serious movement disorder that may not be reversible. The longer you use Zeneril, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
Is Zeneril a controlled substance?
Zeneril 25 mg is not a controlled substance under the Controlled Substances Act.
How to use Zeneril?
Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times a day.