Zifolac

Zifolac Uses, Dosage, Side Effects, Food Interaction and all others data.

Zinc is an essential element in human health with a wide range of roles. It works as a coenzyme for more than 200 enzymes. These enzymes are involved in nucleic acid and protein metabolism and the production of energy. Zinc is vital for growth and development. Zinc deficiency can result in growth retardation, immune dysfunction, increased incidence of infections, anorexia, weight loss, neural tube defects of the foetus, increased risk for abortion and mental lethargy.

Folic Acid is the member of B-vitamin group. Folic Acid participates in several key biological processes, including the synthesis of DNA, RNA and proteins. It is necessary for DNA replication and is involved in the regulation of gene expression. Folic Acid deficiency in pregnant women results in an increased incidence of neural tube defects, including meningomyelocele (e.g., spina bifida), anencephaly, meningocele and craniorachischisis in their neonates. Folic Acid deficiency leads to megaloblastic anemia. Other symptoms and signs of Folic Acid deficiency include weakness, fatigue, irritability, headache, difficulty concentrating, palpitations etc.

Zifolac
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Zifolac
Generic	Folic Acid + Zinc Sulfate Monohydrate
Weight	5mg+20mg
Type	Tablet
Therapeutic Class	Specific mineral & vitamin combined preparations
Manufacturer	Everest Pharmaceuticals Ltd
Available Country	Bangladesh
Last Updated:	September 19, 2023 at 7:00 am

Uses

This is used for the prophylaxis and in the prevention of Zinc and Folic Acid deficiencies.

Zifolac is also used to associated treatment for these conditions: Anaemia folate deficiency, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Latent Iron Deficiency, Neural Tube Defects (NTDs), Vitamin Deficiency, Methotrexate toxicity, Nutritional supplementation

How Zifolac works

Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Dosage

Zifolac dosage

One tablet daily or as recommended by the physician.

May be taken with or without food.

Side Effects

This tablet is well tolerated. Sometimes gastrointestinal disturbance like abdominal pain, dyspepsia, nausea, vomiting, fever and respiratory distress may occur.

Toxicity

IPR-MUS LD₅₀ 85 mg/kg,IVN-GPG LD₅₀ 120 mg/kg, IVN-MUS LD₅₀ 239 mg/kg, IVN-RAT LD₅₀ 500 mg/kg, IVN-RBT LD₅₀ 410 mg/kg

Precaution

Treatment resistance may occur in patients with depressed haematopoiesis, alcoholism, deficiencies of other vitamins. Neonates.

Interaction

Large amount of calcium decreases the absorption of Zinc. In case of Folic Acid, no drug interactions have been reported.

Volume of Distribution

Tetrahydrofolic acid derivatives are distributed to all body tissues but are stored primarily in the liver.

Elimination Route

Folic acid is absorbed rapidly from the small intestine, primarily from the proximal portion. Naturally occurring conjugated folates are reduced enzymatically to folic acid in the gastrointestinal tract prior to absorption. Folic acid appears in the plasma approximately 15 to 30 minutes after an oral dose; peak levels are generally reached within 1 hour.

Elimination Route

After a single oral dose of 100 mcg of folic acid in a limited number of normal adults, only a trace amount of the drug appeared in the urine. An oral dose of 5 mg in 1 study and a dose of 40 mcg/kg of body weight in another study resulted in approximately 50% of the dose appearing in the urine. After a single oral dose of 15 mg, up to 90% of the dose was recovered in the urine. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Small amounts of orally administered folic acid have also been recovered in the feces. Folic acid is also excreted in the milk of lactating mothers.

Pregnancy & Breastfeeding use

Use in pregnancy & lactation: Recommended

Contraindication

Zifolac is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.