Zimulti

Zimulti Uses, Dosage, Side Effects, Food Interaction and all others data.

Zimulti is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Zimulti is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Zimulti is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.

In the RIO-North America trial, 3040 patients were randomized to receive either placebo or one of two doses of rimonabant (5 mg or 20 mg per day). Patients taking 20 mg rimonabant had significant weigh loss, decrease in waist circumference, improved insulin sensitivity, and increases in HDL cholesterol, compared to patients on placebo.

Trade Name Zimulti
Generic Rimonabant
Rimonabant Other Names Rimonabant
Type
Formula C22H21Cl3N4O
Weight Average: 463.787
Monoisotopic: 462.078094435
Protein binding

Almost 100%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country United States, Netherlands
Last Updated: September 19, 2023 at 7:00 am
Zimulti
Zimulti

Uses

For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated risk factors, such as type 2 diabetes or dyslipidaemia.

How Zimulti works

Zimulti is a specific CB1 cannabinoid receptor antagonist. There is considerable evidence that the endocannabinoid (endogenous cannabinoid) system plays a significant role in appetitive drive and associated behaviours. It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders.

Toxicity

Almost twice as many people discontinued rimonabant compared with placebo because of adverse events (13.8% vs. 7.2%). These consistently involved psychiatric disorders (8.5% vs. 3.2%), including depression and anxiety. Other common side effects included insomnia, nausea, vomiting, diarrhoea and fatigue.

Elimination Route

Undetermined

Half Life

6 to 9 days with normal BMI and 16 days if BMI is greater than 30

Innovators Monograph

You find simplified version here Zimulti

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0000436
http://classyfire.wishartlab.com/tax_nodes/C0000087
http://classyfire.wishartlab.com/tax_nodes/C0002019
http://classyfire.wishartlab.com/tax_nodes/C0002564
http://classyfire.wishartlab.com/tax_nodes/C0000195
http://classyfire.wishartlab.com/tax_nodes/C0001030
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0000116
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0001516
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34967
http://www.hmdb.ca/metabolites/HMDB0015623
http://www.genome.jp/dbget-bin/www_bget?drug:D05731
http://www.genome.jp/dbget-bin/www_bget?cpd:C14319
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=104850
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443236
https://www.chemspider.com/Chemical-Structure.94641.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=34967
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL111
https://zinc.docking.org/substances/ZINC000001540228
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC001371
http://www.pharmgkb.org/drug/PA152407999
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=745
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/AY6
https://www.drugs.com/acomplia.html
https://en.wikipedia.org/wiki/Rimonabant
*** Taking medicines without doctor's advice can cause long-term problems.
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