Zinnat Nourrisson
Zinnat Nourrisson Uses, Dosage, Side Effects, Food Interaction and all others data.
Zinnat Nourrisson is one of the bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. It is indicated for the treatment of infections caused by sensitive bacteria.
Zinnat Nourrisson is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Zinnat Nourrisson is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Zinnat Nourrisson axetil is the prodrug
Trade Name | Zinnat Nourrisson |
Availability | Prescription only |
Generic | Cefuroxime |
Cefuroxime Other Names | Cefuroxim, Cefuroxima, Cefuroxime, Cefuroximo, Cefuroximum, Cephuroxime |
Related Drugs | amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin |
Type | |
Formula | C16H16N4O8S |
Weight | Average: 424.385 Monoisotopic: 424.068884198 |
Protein binding | 50% to serum protein |
Groups | Approved |
Therapeutic Class | Second generation Cephalosporins |
Manufacturer | |
Available Country | France |
Last Updated: | September 19, 2023 at 7:00 am |
![Zinnat Nourrisson Zinnat Nourrisson](https://www.medicinesfaq.com/media/png/zinnat-nourrisson.png)
Uses
- Pharyngitis/tonsillitis caused by Streptococcus pyogenes
- Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Moraxella Catarrhalis (including beta-lactamase-producing strains) or Streptococcus pyogenes.
- Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae, or Haemophilus influenzae (nonbeta-lactamase-producing strains only)
- Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli.
- Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis caused by Streptococcus penumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
- Skin and Skin-Structure Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp., and Enterobacter spp.
- Urinary tract infections caused by Escherichia coli or Klebsiella pneumoniae.
- Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
- Gonorrhea : Uncomplicated and disseminated gonococcal infections due to Neiseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains) in both males and females.
- Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi.
- Septicemia caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
- Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseira menintitidis, and Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
- Surgical Prophylaxis: Prophylaxis against infections in abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal and vascular surgery where there is increased risk for infection.
Zinnat Nourrisson is also used to associated treatment for these conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Animal bite, Bacterial Infections, Bloodstream Infections, Bone and Joint Infections, Gonorrhea, Impetigo, Lower Respiratory Tract Infection (LRTI), Lyme Disease, Maxillary Sinusitis, Meningitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Bacterial otitis media, Mild Streptococcal pharyngitis, Mild Streptococcal tonsillitis, Moderate Streptococcal pharyngitis, Moderate Streptococcal tonsillitis
How Zinnat Nourrisson works
Zinnat Nourrisson, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.
Dosage
Zinnat Nourrisson dosage
Oral :
INFECTIONS DOSAGE DURATION
Tablet
(May be administered without regard to meals)
Adolescents & adults(13 years & above)
Pharyngitis or Tonsillitis 250 mg twice daily 5-10 days
Acute bacterial maxillary sinusitis 250 mg twice daily 10 days
Acute bacterial exacerbation of chronic bronchitis 250-500 mg twice daily 10 days
Secondary bacterial infections of acute bronchitis 250-500 mg twice daily 5-10 days
Uncomplicated skin & skin-structure infections 250-500 mg twice daily 10 days
Uncomplicated urinary tract infection 125-250 mg twice daily 7-10 days
Uncomplicated gonorrhea 1000 mg single dose - - -
Lyme disease 500 mg twice daily 20 days
Paediatric patients (Upto12 years)
(Who can swallow tablets whole)
Pharyngitis or Tonsillitis 125 mg twice daily 5-10 days Acute otitis media 250 mg twice daily 10 days
Acute bacterial maxillary sinusitis 250 mg twice daily 10 days
Suspension
(Must be administered with food. Shake the bottle
well before each use)
Paediatric patients (3 months to 12 years)
Pharyngitis or Tonsillitis 20 mg/kg/day in two divided doses 5-10 days Acute otitis media 30 mg/kg/day in two divided doses 10 days
Acute bacterial maxillary sinusitis 30 mg/kg/day in two divided doses 10 days
Injection :
Adult: 750 mg three times daily by IM or IV injection. In severe infections, dose can be increased upto 1.5 gm three times daily by IV injection. The frequency may be increased to four times daily, if necessary, giving total daily doses of 3 to 6 gms.
Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60mg/kg/day is appropriate for most infections.
Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses.
Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia; up to 3 further doses of 750 mg may be given by IV/IM injection every 8 hours for high risk procedures.
Sequential therapy in adults
Pneumonia: 1.5 gm IV injection twice daily for 2-3 days, followed by 500 mg twice daily (oral) for 7-10 days.
Acute exacerbations of chronic bronchitis: 750 mg twice daily (IM or IV injection) for 2-3 days, followed by 500 mg twice daily (oral) for 5-10 days. (Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.)
Other recommendations
In Gonorrhoea: Adult: 1.5g as a single dose (as 2 x 750mg injections intramuscularly with different sites, e.g. each buttock).
In Meningitis: Adults: 3gm IV injection three times daily. Children (above 3 months of age): 200-240 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement. Neonate: 100 mg/kg/day by IV injection reduced to 50 mg /kg/day.
In bone and joint infections: Adult: 1.5 gm IV injection four times daily. Children (above 3 months of age): 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.
In impaired renal function: A reduced dose must be employed when renal function is impaired. Dosage in adults should be determined by the degree of renal impairment and the susceptibility of the causative organism according to the table below -
Creatinine clearance (ml/min) Dose Frequency
> 20 750 mg - 1.5 gm q8h
10-20 750 mg q12h
< 10 750 mg q24h*
* Since Zinnat Nourrisson is dialyzable, patients on hemodialysis should be given a further dose at the end of the dialysis.
In paediatric patients with renal insufficiency, the frequency of dosing should be modified consistent with the recommendations for adults.
Directions for reconstitution:
Shake the bottle well to loosen the powder. Add required amount (with the help of supplied measuring cup) of boiled and cooled water to the dry mixture in the bottle. Shake the bottle vigorously until all the powder is in suspension.
Note: Shake the bottle vigorously before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in a refrigerator and used within 10 days after reconstitution.
Kilbac 250 IM/IV Injection :
Intramuscular injection : Add 1 ml of supplied water for injection BP to the vial and shake.
Intravenous injection: Add 2 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Kilbac 750 IM/IV Injection :
Intramuscular injection : Add 3 ml of supplied water for injection BP to the vial and shake.
Intravenous injection: Add 8 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Kilbac 1.5 IV Injection :
Intravenous injection: Add 16 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Pharmaceutical precaution
Zinnat Nourrisson tablet, powder for suspension and vial (for injection) should be kept in a cool (15° - 30°C) and dry place and protected from light.
Side Effects
Generally Zinnat Nourrisson is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Zinnat Nourrisson may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.
Toxicity
Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.
Precaution
Zinnat Nourrisson should be given with care to patients receiving concurrent treatment with potent diuretics & who have history of colitis.
Interaction
No potentially hazardous interactions have been reported.
Food Interaction
- Take with food. Food increases absorption.
Zinnat Nourrisson Hypertension interaction
[Moderate] Parenteral cefuroxime sodium contains approximately 54.2 mg (2.4 mEq) of sodium per gram of cefuroxime activity.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
Zinnat Nourrisson Drug Interaction
Unknown: amoxicillin / clavulanate, amoxicillin / clavulanate, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, acetaminophen, acetaminophen, montelukast, montelukast, budesonide / formoterol, budesonide / formoterol, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, cetirizine, cetirizine
Zinnat Nourrisson Disease Interaction
Major: colitisModerate: renal dysfunction, dialysis, ferricyanide tests, seizure disorders, sodium, liver disease, prolonged PT
Elimination Route
Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).
Half Life
Approximately 80 minutes following intramuscular or intravenous injection.
Pregnancy & Breastfeeding use
Pregnancy: While all antibiotics should be avoided in the first trimester if possible. However, Zinnat Nourrisson has been safely used in later pregnancy to treat urinary and other infections.
Nursing mothers: Zinnat Nourrisson is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind
Contraindication
Zinnat Nourrisson is contraindicated in patients with known allergy to Cephalosporins.
Acute Overdose
Excessively large doses of all Cephalosporins can cause cerebral irritation and may cause convulsions. This complication is unlikely to occur in routine practice unless the patient is in renal failure. Hemodialysis or peritoneal dialysis can remove Zinnat Nourrisson.
Interaction with other Medicine
Concomitant administration of probenecid with Zinnat Nourrisson increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Zinnat Nourrisson and tend to cancel the effect of postprandial absorption.
Storage Condition
Tablet: Store below 30° C, protected from light and moisture.
Suspension: Store below 25° C, protected from light and moisture.
Injection: Store below 25° C, protected from light and moisture. Use reconstituted solution immediately. The reconstituted solution is stable for 2 hours at room temperature and for 12 hours when refrigerated at 2° - 8° C.
Innovators Monograph
You find simplified version here Zinnat Nourrisson
Zinnat Nourrisson contains Cefuroxime see full prescribing information from innovator Zinnat Nourrisson Monograph, Zinnat Nourrisson MSDS, Zinnat Nourrisson FDA label
FAQ
What is Zinnat Nourrisson used for?
Zinnat Nourrisson is used to treat certain infections caused by bacteria, such as bronchitis, gonorrhea, Lyme disease,and infections of the skin, ears, sinuses, throat, tonsils, and urinary tract.
How safe is Zinnat Nourrisson?
Zinnat Nourrisson comes with risks if you don't take it as prescribed. If you stop taking the drug suddenly or don't take it at all your infection may continue or get worse.
How does Zinnat Nourrisson work?
Zinnat Nourrisson works by stopping the growth of bacteria. Antibiotics such as Zinnat Nourrisson will not work for colds, flu, or other viral infections.
What are the common side effects of Zinnat Nourrisson?
Nausea, vomiting, diarrhea, strange taste in the mouth, or stomach pain may occur. Diaper rash may occur in young children. Dizziness and drowsiness may occur less frequently, especially with higher doses. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Is Zinnat Nourrisson safe during pregnancy?
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Use is recommended only if clearly needed and the benefit outweighs the risk to the fetus.
Is Zinnat Nourrisson safe during breastfeeding?
Zinnat Nourrisson is acceptable in nursing mothers.
Can I drink alcohol with Zinnat Nourrisson?
There is no 'do not drink alcohol' warning that applies to taking Zinnat Nourrisson because it doesn't specifically affect the medicine itself.
Can I drive after taking Zinnat Nourrisson?
Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
How long does it take Zinnat Nourrisson to kick in?
Zinnat Nourrisson will start working right away to fight the infection in your body. You should start to feel better after 2 days, but continue to take the full course of your medication even if you feel like you don't need it anymore.
How long does Zinnat Nourrisson stay in my body?
Zinnat Nourrisson has a half-life of eight hours before being excreted in the urine. The typical dose of Zinnat Nourrisson is 250 mg every six hours, with treatment lasting from 7 to 14 days.
When should be taken of Zinnat Nourrisson?
Zinnat Nourrisson is usually taken every 12 hours for 5-10 days, depending on the condition being treated. To treat gonorrhea, Zinnat Nourrisson is taken as a single dose, and to treat Lyme disease, Zinnat Nourrisson is taken every 12 hours for 20 days.
Can I take Zinnat Nourrisson on an empty stomach?
You may take Zinnat Nourrisson oral with or without food.
Can I take Zinnat Nourrisson for a long time?
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Who should not take Zinnat Nourrisson?
Don’t take Zinnat Nourrisson again if you’ve ever had an allergic reaction to it before. Taking it again could be fatal.
Can I take overdose of Zinnat Nourrisson?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
What happens if I forget to take my Zinnat Nourrisson?
Skipping doses can increase your risk of infection that is resistant to medication. Zinnat Nourrisson will not treat a viral infection such as the flu or a common cold.
What should if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use take doses at one time.Call your doctor for instructions if you miss a Zinnat Nourrisson injection.
What happen If I stop taking Zinnat Nourrisson?
If you stop taking Zinnat Nourrisson suddenly or don't take it at all Your infection may continue or get worse.