Zioptan

Zioptan Uses, Dosage, Side Effects, Food Interaction and all others data.

Zioptan, a prostaglandin analog is a selective FP prostanoid receptor agonist which is believed to reduce intraocular pressure by increasing uveoscleral outflow of aqueous humor.

Zioptan is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. Zioptan has an affinity for the FP receptor that is approximately 12 times higher than that of the carboxylic acid of latanoprost, but with almost no potential to bind to other receptors.

Zioptan
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Zioptan
Generic	Tafluprost
Tafluprost Other Names	Tafluprost
Weight	0.0015%,
Type	Ophthalmic solution
Formula	C₂₅H₃₄F₂O₅
Weight	Average: 452.5313 Monoisotopic: 452.237430608
Groups	Approved
Therapeutic Class	Drugs for miotics and glaucoma
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Zioptan is used for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Zioptan is also used to associated treatment for these conditions: Increased Intra Ocular Pressure (IOP), Ocular Hypertension

How Zioptan works

Zioptan acid is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and humans suggest that the main mechanism of action is increased uveoscleral outflow.

Dosage

Zioptan dosage

Instill one drop in the affected eye(s) once daily in the evening.

Side Effects

The most frequently reported treatment-related side effect is ocular hyperemia. Rare side effects observed include eye irritation and blurred vision.

Toxicity

Most common ocular adverse reaction is conjunctival hyperemia (range 4% – 20%).

Precaution

For ophthalmic use only.
To avoid possible contamination of the drops, do not touch the dropper tip or to any surface.
Should be used with caution in patients with active intraocular inflammation (e.g., iritis/uveitis).
If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes between applications.

Food Interaction

No interactions found.

Volume of Distribution

The highest concentration of tafluprost acid was found in the cornea and conjunctiva.

Elimination Route

Following instillation, tafluprost is absorbed through the cornea and is hydrolyzed to the biologically active acid metabolite, tafluprost acid. Zioptan is an ester which makes the drug lipophillic enough to be quickly absorbed through. When administered to the eye, the peak plasma concentration (Cmax) and time to peak plasma concentration (Tmax) of tafluprost acid in healthy subjects was 26 pg/mL and 10 minutes respectively. a AUC, tafluprost acid = 394 pgmin/mL - 432 pgmin/mL.

Elimination Route

Mean plasma tafluprost acid concentrations were below the limit of quantification of the bioanalytical assay (10 pg/mL) at 30 minutes following topical ocular administration of tafluprost 0.0015% ophthalmic solution. In male rats, it was observed that tafluprost was excreted into the feces.

Pregnancy & Breastfeeding use

Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Zioptan ophthalmic solution should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not known whether Zioptan is excreted in human milk. Caution should be exercised while giving this ophthalmic solution to a nursing mother.

Contraindication

Zioptan ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product.

Special Warning

Use in children: Use in pediatric patients is not recommended.

Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.

Innovators Monograph

You find simplified version here Zioptan

Zioptan contains Tafluprost see full prescribing information from innovator Zioptan Monograph, Zioptan MSDS, Zioptan FDA label

FAQ

What is Zioptan used for?

Zioptan ophthalmic is used to treat glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision) and ocular hypertension (a condition which causes increased pressure in the eye).

What are the side effects of Zioptan eye drops?

Side Effects:

Blurred vision.
burning, dry, or itching eyes.
decreased vision.
eye discharge or excessive tearing.
eye pain.
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid.

How Zioptan works?

Zioptan is in a class of medications called prostaglandin analogs.Zioptan works lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye.It is in a class of medications called prostaglandin analogs.

Is safe Zioptan during pregnancy?

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.

Is Zioptan safe during breasfeeding?

Zioptan is not likely to reach the breastmilk or bloodstream of the infant or to cause any adverse effects in breastfed infants. Professional guidelines consider prostaglandin eye drops acceptable during breastfeeding.

How do you use Zioptan?

Zioptan is usually instilled in the affected eye(s) once a day in the evening. Use Zioptan at around the same time in the evening every day.

What are the indications of Zioptan?

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.