Zobactam
Zobactam Uses, Dosage, Side Effects, Food Interaction and all others data.
Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.
Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
| Trade Name | Zobactam |
| Generic | Piperacillin + Tazobactam Sodium Salt |
| Type | |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Greece |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Piperacillin is a penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria.
For the treatment of polymicrobial infections.
Zobactam is also used to associated treatment for these conditions: Animal bite, Complicated Appendicitis, Pelvic Inflammatory Disease (PID), Peritonitis, Postpartum Endometritis, Surgical Site Infections, Moderate Bacterial Infections, Moderate Community acquired pneumonia, Moderate Nosocomial pneumonia, Severe Bacterial Infections, Severe Nosocomial pneumonia, Uncomplicated skin and subcutaneous tissue bacterial infections
How Zobactam works
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.
Volume of Distribution
- 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
Elimination Route
Not absorbed following oral administration.
Half Life
36-72 minutes
Clearance
- 32 - 41 mL/min/1.73 m2
- 124 - 160 mL/min/1.73 m2 [older pediatric patients]
Elimination Route
As with other penicillins, PIPRACIL is eliminated primarily by glomerular filtration and tubular secretion; it is excreted rapidly as unchanged drug in high concentrations in the urine. Because PIPRACIL is excreted by the biliary route as well as by the renal route, it can be used safely in appropriate dosage in patients with severely restricted kidney function.
Innovators Monograph
You find simplified version here Zobactam
