Zoderm E

Zoderm E Uses, Dosage, Side Effects, Food Interaction and all others data.

Cream contains the antifungal active compound Zoderm E Nitrate. For topical dermatological use only. Zoderm E Nitrate is an imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has in vitro activity against a wide range of pathogenic fungi. Zoderm E has been shown to be active against most strains of the following organisms both in vitro and in clinical infections at indicated body sites: Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Malassezia furfur. Zoderm E exhibits satisfactory in vitro minimum inhibitory concentrations (MICs) against most strains of the following organisms: Microsporum audouini, Microsporum canis, Microsporum gypseum, Trichophyton tonsurans,Trichophyton violaceum.

Zoderm E is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.

Zoderm E
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Zoderm E
Generic	Oxiconazole
Oxiconazole Other Names	Oxiconazol, Oxiconazole, Oxiconazolum
Type	Cream, Lotion
Formula	C₁₈H₁₃Cl₄N₃O
Weight	Average: 429.12 Monoisotopic: 426.9812729
Groups	Approved
Therapeutic Class	Topical Antifungal preparations
Manufacturer	Glaxosmithkline Pharma
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Zoderm E cream is used for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. Zoderm E Cream is used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur.

Zoderm E is also used to associated treatment for these conditions: Fungal skin infection, Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis

How Zoderm E works

Zoderm E inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Zoderm E has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Zoderm E can increase membrane permeability to zinc, augmenting its cytotoxicity.

Dosage

Zoderm E dosage

Cream should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Zoderm ECream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.

Use Zoderm E cream as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Zoderm E cream isfor external use only.

Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks orsooner if the condition worsens.

Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.

Avoid the use of occlusive dressings unless otherwise directed by the physician.

Do not use this medication for any disorder other than that for which it was prescribed

Side Effects

Pruritus, burning, irritation and allergic contact dermatitis, folliculitis, erythema, and papules, fissure, maceration, rash, stinging and nodules.

Toxicity

Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.

Precaution

Zoderm E cream is not for ophthalmic or intravaginal use.

Interaction

Potential drug interactions between Zoderm E and other drugs have not been systematically evaluated.

Food Interaction

No interactions found.

Elimination Route

Systemic absorption of oxiconazole is low.

Pregnancy & Breastfeeding use

Pregnancy category B. Because Zoderm E Nitrate is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.