Zonat
Zonat Uses, Dosage, Side Effects, Food Interaction and all others data.
Zonat is a tetraene polyene antibiotic derived from Streptomyces natalensis. Zonat probably exerts its antifungal effects by binding to sterols in the fungal cell membrane to produce a change in membrane permeability that allows loss of essential cellular constituents. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, Zonat is predominantly fungicidal. Topical administration appears to produce effective concentration of Zonat within the corneal stroma but not in intraocular fluid.
Zonat is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Zonat is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
| Trade Name | Zonat |
| Generic | Natamycin |
| Natamycin Other Names | Natamicina, Natamycin, Natamycine, Natamycinum, Pimaracin, Pimaricin |
| Type | Eye Drops |
| Formula | C33H47NO13 |
| Weight | Average: 665.733 Monoisotopic: 665.304740577 |
| Groups | Approved |
| Therapeutic Class | Ophthalmic antibacterial drugs |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zonat sterile ophthalmic suspension is used for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by susceptible organisms including Fusarium solani.
Zonat is also used to associated treatment for these conditions: Fungal Keratitis, Fungal blepharitis, Fungal conjunctivitis
How Zonat works
Like other polyene antibiotics, Zonat inhibits fungal growth by binding to sterols. Specifically, Zonat binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.
Dosage
Zonat dosage
For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated.
For fungal blepharitis & conjunctivitis: Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient.
Side Effects
Eye irritation, eye discomfort, eye edema, conjunctival chemosis and hyperemia has been reported.
Precaution
For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to natamycin.
Interaction
May increase spread of fungal eye infection when used with topical corticosteroid.
Food Interaction
No interactions found.Elimination Route
Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.
Pregnancy & Breastfeeding use
Pregnancy Category C. Zonat sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.
Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when Zonat is administered to a nursing mother.
Contraindication
Zonat ophthalmic suspension is contraindicated in individuals with a history of hypersensitivity to any of its component.
Special Warning
Pediatric: Safety and effectiveness in paediatric patients have not been established.
Storage Condition
Store in a cool and dry place. Protect from light. Do not freeze. Do not use for longer than one month after first opening of the bottle.
Innovators Monograph
You find simplified version here Zonat
Zonat contains Natamycin see full prescribing information from innovator Zonat Monograph, Zonat MSDS, Zonat FDA label
