Zoomval Crono
Zoomval Crono Uses, Dosage, Side Effects, Food Interaction and all others data.
Zoomval Crono shows antiepileptic properties in various types of seizures. The exact mechanism of Zoomval Crono is not yet established. However it is suggested that its activity is related to increased brain levels of Gama Amino Butyric Acid (GABA).
| Trade Name | Zoomval Crono |
| Generic | Sodium Valproate |
| Type | Tablet |
| Therapeutic Class | Primary anti-epileptic drugs |
| Manufacturer | S,p Pharma |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zoomval Crono is used for -
- Epilepsy: All types of epilepsy such as Absence seizure, Myoclonic seizure, Tonic-clonic seizure, Atonic, Mixed, simple or generalized, Secondary generalized seizure etc.
- Mania: For the treatment of manic episodes of bipolar disorders.
- Other: As an alternative treatment for febrile convulsion & migraine prophylaxis.
Dosage
Zoomval Crono dosage
Oral:
Adults:
- Initial: 600 mg/day in 2 divided doses, preferably after food. Dose may be increased by 200mg/day at 3 days interval to a maximum of 2.5 gm daily in divided doses until control of seizure is achieved.
- Maintenance dose: Usually 1-2 gm daily (20-30 mg/kg daily).
Children (up to 20 kg):
- Initial: 20 mg/kg daily in divided doses. Dose may be increased in severe cases with proper monitoring of plasma concentration.
Children (over 20 kg):
- Initial: 400 mg/ day (irrespective of weight). Dose may be increased by 20-30 mg/ kg if required to achieve control.
Injection:
Zoomval Crono is for intravenous use only. Use of Zoomval Crono for periods of more than 14 days has not been studied. Patients should be switched to oral valproate products as soon as it is clinically feasible.
Zoomval Crono should be administered as a 60 minute infusion (but not more than 20 mg/min) with the same frequency as the oral products, although plasma concentration monitoring and dosage adjustments may be necessary.
In one clinical safety study, approximately 90 patients withepilepsyand with no measurable plasma levels of valproate were given single infusions of Zoomval Crono (up to 15 mg/kg and mean dose of 1184 mg) over 5-10 minutes (1.5-3.0 mg/kg/min). Patients generally tolerated the more rapid infusions well. This study was not designed to assess the effectiveness of these regimens.
Side Effects
Gastric irritation, nausea, ataxia & tremor; hyperammonaemia, increased appetite & weight gain; transient hair loss, oedema, thrombocytopenia, and inhibition of platelet aggregation, impaired hepatic function leading rarely to fetal hepatic failure; rashes; sedation; rarely lethargy and confusion and also increased alertness; rarely pancreatitis, leucopenia, pancytopenia, red cell hypoplasia, fibrinogen reduction; irregular periods, amenorrhoea, gynaecomastia, toxic epidermal necrolysis, hearing loss, Fancoli's syndrome, dementia, Steven's-Johnson syndrome, and vasculitis have also been reported.
Precaution
Liver function should be monitored before therapy and during first six months, especially in those patients who seem most at risk. Blood tests are recommended before surgery. Renal impaired patients, pregnant and brest feeding mother should be specially cared. Valproate is eliminated mainly through the kidney, partly in the form of ketone bodies which may lead to false statement in urine ketone test. Sudden withdrawal of therapy should be avoided
Interaction
Zoomval Crono is a non specific inhibitor of drug metabolism. Phenobarbital, Phenytoin, Warfarin, Aspirin etc. interacts with Zoomval Crono.
Pregnancy & Breastfeeding use
Zoomval Crono crosses the placenta in humans which may lead to neural tube defects such as anencephaly and spina bifida if exposed in the first trimester. Zoomval Crono may excrete in breast milk. So treatment with Zoomval Crono may cause harm to new born baby.
Contraindication
Zoomval Crono is contra-indicated in patients with known hypersensitivity of Zoomval Crono, personal or family history of severe active liver disease, hepatic dysfunction, porphyria and known urea cycle disorder.
Storage Condition
Syrup: Store below 30° C, protected from light.
Tablet: Store below 30° C, protected from light. Keep all medicines out of the reach of children.
Innovators Monograph
You find simplified version here Zoomval Crono
FAQ
What is Zoomval Crono used for?
Zoomval Crono used to treat epilepsy and bipolar disorder. It's occasionally used to prevent migraine headaches. This medicine is only available on prescription.
How safe is Zoomval Crono?
Many people can take Zoomval Crono safely for many months or years. However, there are potential side effects that can happen over a long time. Long-term treatment with Zoomval Crono can cause osteoporosis and osteopenia.
How long does it take for sodium valproate to work?
Zoomval Crono may take several days to show an initial effect and in some cases may take from two to six weeks for maximum effect. Treatment is started with low doses and may be increased over a couple of weeks according to your child's response.
What are the common side effects of Zoomval Crono?
The common side effects of Zoomval Crono are include:
- stomach pain, feeling or being sick
- diarrhoea
- dry or sore mouth, or swollen gums
- shakes (tremors) in a part of your body, or unusual eye movements
- feeling tired or sleepy
- headache
- weight gain
- thinning hair, or changes to the colour or texture of your hair
- irregular or delayed periods
How to take Zoomval Crono?
Zoomval Crono comes as slow release (prolonged or sustained release) tablets, capsules and granules, gastro-resistant tablets, crushable tablets, and as a liquid.
Slow release medicine passes into your body gradually.
When is the best time to take Zoomval Crono?
You can take Zoomval Crono with or without food, but it's best to stick to the same way each time. Do not take it with food some days and without food on other days.
How often can I take Zoomval Crono?
If you're taking Zoomval Crono once a day, you can choose a time that suits you. Just try to keep to the same time every day.
If you're taking Zoomval Crono twice a day, try to leave a gap of 10 to 12 hours between doses. For example you could take your first dose in the morning (between 7am and 8am) and your second dose in the evening (between 7pm and 8pm).
Is Zoomval Crono safe during pregnancy?
Zoomval Crono is not recommended in pregnancy, as it can cause birth defects and problems with your baby's learning and behaviour.
If there's a chance you could become pregnant while taking this medicine, your doctor will put you on Prevent, the Zoomval Crono prevention programme.
Is Zoomval Crono safe during breastfeeding?
If your doctor or health visitor says your baby is healthy you can take Zoomval Crono while breastfeeding.
Zoomval Crono passes into breast milk in small amounts but it's unlikely to harm your baby so you can continue breastfeeding if your doctor says you need to take it.
How long will I take Zoomval Crono?
Once your condition is under control, you'll usually need to keep taking Zoomval Crono for many years.
Is Zoomval Crono safe to take it for a long time?
Many people can take Zoomval Crono safely for many months or years.
However, there are potential side effects that can happen over a long time. Long-term treatment with Zoomval Crono can cause osteoporosis and osteopenia.
What will happen when I come off Zoomval Crono?
Do not stop taking Zoomval Crono suddenly, unless your doctor tells you to.
You're unlikely to get any extra symptoms when you stop taking this medicine. However, if you're taking Zoomval Crono for epilepsy, it's possible that you'll get seizures again once you stop taking it. You can prevent these withdrawal seizures by reducing your dose of Zoomval Crono gradually.
Can I drink alcohol with Zoomval Crono?
Drinking alcohol while taking Zoomval Crono may make you feel sleepy or tired. It's best to stop drinking alcohol during the first few days, until you see how the medicine affects you.
Will Zoomval Crono affect my fertility?
Zoomval Crono can reduce fertility in both men and women. Once you stop taking this medicine, your fertility will return.In men Zoomval Crono has been reported to cause infertility.
Will Zoomval Crono affect my contraception?
Zoomval Crono does not affect any type of contraception, including the combined pill and emergency contraception.If there's a chance you could become pregnant while taking Zoomval Crono you must use contraception. Your doctor will put you on Prevent, the valproate pregnancy prevention programme.
Can I drive after taking Zoomval Crono?
You may feel sleepy, tired or dizzy when you first start taking Zoomval Crono. This may also happen if your dose has increased. If you're affected, do not drive or ride a bike until you feel more alert.
Can I take too much dose of Zoomval Crono?
Taking too much Zoomval Crono can lead to symptoms such as: feeling or being sick, headaches or feeling dizzy,muscle weakness.
What happen If I missed Zoomval Crono?
If you've missed a dose, what you do next depends on whether you usually take your medicine once or twice a day. If you take Zoomval Crono once a day ,take the forgotten dose as soon as you remember unless it's within a few hours of the next dose.
Who should not take Zoomval Crono?
You should not use Zoomval Crono if you are allergic to it.
