Zoyalife M
Zoyalife M Uses, Dosage, Side Effects, Food Interaction and all others data.
Astaxanthin acts as an antioxidant by dual mode of action. It suppresses singlet oxygen and also inhibits lipid peroxidation. By these actions it reduces the harmful free radicals. Therefore acts as a very strong antioxidant. Astaxanthin is absorbed by passive diffusion into the intestinal epithelium alongside fatty acids. Then it is incorporated into lipoproteins, transported to the liver, via lymph and blood and partly resecreted with lipoproteins. More than 70% of the Astaxanthin is contained in high-density lipoprotein part of plasma. Highest concentration of Astaxanthin is in the small intestine, followed by subcutaneous fat, spleen, liver, heart, kidney and skin and lowest in the muscles.
Coenzyme Q10 is an essential cofactor in the mitochondrial electron transport chain, where it accepts electrons from complex I and II, an activity that is vital for the production of ATP.
Ubidecarenon has roles in many prysiological process including sulfide oxidation, regulation of mitochondrial permeability transition pore and translocation of protons and calcium ions accross biological membranes. Studies have shown its benefitial effect in treating cancer, statin myopathy, congestive heart failure and hypertension.
Trade Name | Zoyalife M |
Generic | Astaxanthin + L-carnitine + Ubidecarenone + Zinc Ascorbate |
Weight | 8mg |
Type | Tablet |
Therapeutic Class | |
Manufacturer | Intra Labs Ltd |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Astaxanthin is used to-
1. Strong antioxidant
2. Improves cardiovascular health (Atherosclerosis, reduce cholesterol).
3. Improves immune function.
4. Improves condition of skin
5. Protects skin from damage caused by sun (Reduce wrinkles, pimples and other signs of aging)
6. Improves recovery from central nervous system injuries
7. Protects from Parkinson ’s disease, Dementia and Alzheimer\'s
8. Protects eyes from cataracts and macular degeneration.
9. Reduces inflammation (Arthritis)
10. Reduces risk of infertility
Also Astaxnthin effectively reduce oxidative damage to DNA, decrease the risk for many types of cancer and stabilize blood sugar.
HMG CoA reductase inhibitors mediated decreased level of Coenzyme Q10 in blood, Drug induced Myopathy, Protects body against free radical damage with its antioxidant property, Adjuvant therapy in cardiovascular disease especially in angina and congestive heart failure, Immune system depression, Cognitive decline, Useful in the management of Periodontal Disease
Zinc ascorbate is a medication used to prevent the absorption of copper in Wilson's disease and also as part of natural health products.
Zoyalife M is also used to associated treatment for these conditions: MigraineNutritional supplementation
How Zoyalife M works
Ubidecarenone is an essential cofactor in the mitochondrial electron transport chain. Its functions are the acceptance of electrons from the complex I and II and this activity is vital for the production of ATP. It acts as a mobile redox agent shuttling electrons and protons in the electron transport chain. Ubidecarenone also presents antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes as well as inhibiting oxidation of LDL-cholesterol.
Dosage
Zoyalife M dosage
Adults (18 years and older) - Daily dose is 4mg. should be taken along with or immediately prior to meals in the morning.
Different dose for various use are given below:
4 mg: Used as a strong antioxidant, improves cardiovascular health (Atherosclerosis, reduce cholesterol), improves immune function.
4-8 mg: Improves condition of skin, protects skin from sun damage (Reduce wrinkles, pimples and other signs of aging), improves recovery from central nervous system injuries and protects eyes from cataracts and macular degeneration.
8-12 mg: Reduces inflammation (Arthritis)
16 mg: Reduces risk of infertility
The recommended dose of Co-enzyme Q10 is:
For Co-enzyme Q10 deficiency:150 mg daily.
For mitochondrial disorders:150-160 mg, or 2 mg/kg/day.
For heart failure in adults:100 mg per day divided into 2 or 3 doses.
For recent myocardial infarction:120 mg daily in 2 divided doses.
For high blood pressure:120-200 mg per day divided into 2 doses.
For isolated systolic hypertension:60 mg twice daily.
For preventing migraine headache:100 mg three times daily.
For Parkinsons disease:300 mg, 600 mg, 1200 mg and 2400 mg per day in 3-4 divided doses.
For infertility in men:200-300 mg per day.
For muscular dystrophy:100 mg per day.
Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help to reduce side effects.
Side Effects
No severe side effects have been reported yet
Coenzyme Q10 is well tolerated and having no significant side effects. Mild gastrointestinal symptoms such as nausea, diarrhea and epigastric distress have been reported.
Toxicity
There have not been reports of adverse events of diet supplementation with ubidecarenone. The normal side effects reported in humans are related to the gastrointestinal tract.
Precaution
Pregnant women and nursing mothers should avoid Astaxanthin containing supplements.
Supplemental Coenzyme Q10 may improve beta-cell function and glycemic control in type II diabetics. Therefore, those diabetic patients who do use supplemental Coenzyme Q10 should determine by appropriate monitoring if they need to make any adjustments in their diabetic medications.
Interaction
Concomitant intake of Astaxanthin with Cholestyramine, Colestipol, Mineral oil, Orlistat may reduce the absorption rate of Astaxanthin
Warfarin: Supplemental Coenzyme Q10 may decrease the effectiveness of Warfarin.
Statins: The statin drugs are known to decrease Coenzyme Q10 levels in humans.
Doxorubicin: Coenzyme Q10 may increase the cardiotoxicity of doxorubicin.
Antidiabetic medications: Coenzyme Q10 may improve glycemic control in some type II diabetics. If this were to occur, antidiabetic medications might need appropriate adjusting
Volume of Distribution
Ubidecarenone is distributed to the various tissues of the body and it is able to enter the brain. In preclinical studies with intravenous administration of ubidecarenone, it is reported a volume of distribution of 20.4 L/kg which reflects its ability to penetrate extensively into organs and tissues. AS a general rule, tissues with high-energy requirements or metabolic activity tend to presents higher amounts of ubidecarenone, these organs can be heart, kidney, liver and muscle.
Elimination Route
Ubidecarenone is absorbed from the small intestine into the lymphatics and then it can enter the blood. The hydrophobicity and large molecular weight limit its absorption making it very poor and variable depending on the food intake and the number of lipids presented in the food. The absorption is lower in the presence of an empty stomach and greater in presence of high lipid food diet. The daily dosage of ubidecarenone presents the reach of maximal serum concentration by reaching a plateau after three weeks. The pharmacokinetic properties may vary between different brands but studies have reported an AUC of 11.51 mcg h/ml and a Cmax of 0.32 mcg/ml at a time of 7.9 h.
Half Life
The pharmacokinetic properties may vary between different brands but studies have reported a half-life of ubidecarenone of 21.7 h.
Clearance
In preclinical studies with intravenous administration of ubidecarenone, it is reported a total clearance of 1.18 ml h/kg which was indicative of a prolonged elimination.
Elimination Route
The main elimination route of ubidecarenone is through the bile. After its oral administration, over 60% of the dose is excreted in the feces in the form of unchanged ubidecarenone and a small fraction of the metabolites. In the urine, ubidecarenone is bound to saposin B protein and represents only 8.3% of the total administered dose.
Pregnancy & Breastfeeding use
Both pregnant women and lactating mothers should avoid Astaxanthin supplements as no data on safety has been found yet
Because of lack of information on long-term safety, pregnant women and nursing mothers should avoid Coenzyme Q10.
Contraindication
Contraindicated for those with known allergies to Astaxanthin
Patients with a known hypersensitivity to any component of this product
Acute Overdose
No case of overdose has occurred with Astaxanthin
Storage Condition
Store in cool and dry place, away from direct light. Keep out of reach of children.
Store in a cool & dry place, protect from light & moisture. Keep out of the reach of children.
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