Zygomycin A1
Zygomycin A1 Uses, Dosage, Side Effects, Food Interaction and all others data.
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Zygomycin A1 is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
Trade Name | Zygomycin A1 |
Availability | Prescription only |
Generic | Paromomycin |
Paromomycin Other Names | Aminosidin, Aminosidine, Catenulin, Crestomycin, Estomycin, Hydroxymycin, Monomycin A, Neomycin E, Paromomicina, Paromomycin, Paromomycin I, Paromomycine, Paromomycinum, Paucimycin, Paucimycinum, Zygomycin A1 |
Related Drugs | doxycycline, metronidazole, Flagyl, albendazole, neomycin, Vibramycin, tinidazole, nitazoxanide, praziquantel, niclosamide |
Type | |
Formula | C23H45N5O14 |
Weight | Average: 615.6285 Monoisotopic: 615.296301173 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zygomycin A1 is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Zygomycin A1 is also used to associated treatment for these conditions: Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis
How Zygomycin A1 works
Zygomycin A1 inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Food Interaction
- Take with food.
Zygomycin A1 Drug Interaction
Unknown: lactobacillus acidophilus, lactobacillus acidophilus, nitazoxanide, nitazoxanide, amoxicillin / clavulanate, amoxicillin / clavulanate, dicyclomine, dicyclomine, glucose, glucose, amitriptyline, amitriptyline, lamivudine, lamivudine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, crofelemer, crofelemer, enfuvirtide, enfuvirtide
Zygomycin A1 Disease Interaction
Elimination Route
Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Innovators Monograph
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