Zynapse
Zynapse Uses, Dosage, Side Effects, Food Interaction and all others data.
Zynapse is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue. Zynapse promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism. Zynapse seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Zynapse might also decrease brain tissue damage when the brain is injured.
| Trade Name | Zynapse |
| Availability | Over the counter |
| Generic | Citicoline |
| Citicoline Other Names | CDP-choline, CDP-colina, citicolina, Citicoline, citidin difosfato de colina |
| Type | |
| Formula | C14H26N4O11P2 |
| Weight | Average: 488.324 Monoisotopic: 488.107330718 |
| Groups | Approved, Experimental |
| Therapeutic Class | CNS stimulant drugs |
| Manufacturer | |
| Available Country | Philippines |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Use for the improvement of thinking, learning and memory in people suffering from Alzheimer's disease, dementia, head trauma, Parkinson's disease and glaucoma. Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.
Zynapse is also used to associated treatment for these conditions: Degenerative Brain Disorder, Parkinsonian Syndromes
Dosage
Zynapse dosage
Disturbance of Consciousness: Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.
Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician.
Side Effects
Rash, Insomnia, headache, dizziness, convulsion, Nausea, anorexia, Abnormal liver function in laboratorium measurement, Diplopia, Flushing, transient blood pressure changes or malaise.
Precaution
In acute and emergency condition, citicoline should be administered. In conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continue, avoid giving high-dose citicoline (>500 mg concomitantly), since it may exaggerate blood flow in brain. In case small dose of citicoline (100-500 mg 2-3 times daily) may be needed.
Precaution should be given in patients with hypersensitivity. For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection recommended within 2 weeks after apoplectic stroke.
Use in pregnancy: Zynapse is avoided in pregnancy.
Use in lactation: Zynapse is avoided by nursing mothers.
Interaction
Zynapse potentiates the effects of L-dopa.
Pregnancy & Breastfeeding use
There is inadequate evidence of safe use of citicoline in human pregnancy. Zynapse should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
Contraindication
Hypersensitivity to citicoline sodium or to any of the excipients of Zynapse.
Storage Condition
Store below 25° C
Innovators Monograph
You find simplified version here Zynapse
FAQ
What is Zynapse used for?
Zynapse used to treat traumatic brain injures, stroke, vascular dementia, Parkinson's disease, and brain aging where it has the function of stabilizer of cell membranes and reduces the presence of free radicals. Zynapse help memory loss due to aging, improve vision in people with glaucoma, and help with recovery in stroke patients. It is also used for Alzheimer disease, bipolar disorder, lazy eye, and other conditions of the brain.
How safe is Zynapse?
No serious safety issues have been reported with citicoline treatment. In fact, in a meta-analysis of trials for cerebral dysfunction in elderly people, citicoline tended to be more tolerable than the placebo. However, the safety of long-term Zynapse citicoline supplementation is not known.
What are the common side effects of Zynapse?
Common side effects of Zynapse such as trouble sleeping, headache, constipation, diarrhea, nausea, stomach pain, blurred vision, chest pains, and others.
Is Zynapse safe during pregnancy?
Women who are pregnant should avoid using Zynapse.
Is Zynapse safe during breastfeeding?
There isn't enough reliable information to know if Zynapse is safe to use when breast-feeding. Stay on the safe side and avoid use.
When should be taken of Zynapse?
Stroke patients who take Zynapse by mouth or by IV within 24 hours of having the kind of stroke that is caused by a clot (ischemic stroke) may be more likely to have a complete recovery within 3 months.
Is Zynapse taken with food?
May be taken with or without food.
How much Zynapse can I take daily?
Oral dosages of 250 to 2,000 mg daily have been evaluated in adolescents and adults in clinical trials. Lower doses have been used in short-term trials with combination therapy in patients with major depressive disorder.
How long does it take Zynapse to work?
Zynapse administration of at least 6 months.
Does Zynapse help memory?
According to the present results, showing that Zynapse improves memory performance in elderly subjects, we concluded that this molecule is suitable for the treatment of memory deficits in old people.
How long does Zynapse take to work?
Some people will notice results in as little as 3 to 5 days, but most users will see results in no later than 15 days.
How long does Zynapse take to work?
Elimination half-life of citicoline is 3.5 hrs (1st peak concentration), 125 hrs (2nd peak concentration).
How long is Zynapse taken?
Zynapse possibly safe when taken by mouth short-term (up to 90 days).
How should I take Zynapse?
Zynapse is taken by mouth as a supplement or given as an injection into the vein (by IV) or as a shot into the muscle.
Who should not take Zynapse?
Do not take Zynapse if you have any known allergy to Zynapse or any other psychostimulant drugs. Inform your doctor if you are taking any prescription or non-prescription drugs, nutritional supplements, or herbal products. Inform your doctor if you are pregnant or breastfeeding.
Can I take Zynapse for a long time?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
What happen If I missed dose of Zynapse?
Try not to skip a dose of Zynapse. If a dose is skipped, do not add it up to the next dose. Since Zynapse is administered in a hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.
What happens if I overdose of Zynapse?
Seek emergency medical treatment or contact your doctor in case of an overdose. Since Zynapse is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
Can Zynapse affect my kidneys?
Use Zynapse with caution if you have kidney problems. Impaired kidney function may lead to slow elimination and accumulation of this medicine in your body. Your doctor may prescribe a suitable dose based on your health condition.
Can Zynapse affects my liver?
Use Zynapse with caution if you have liver problems. In such cases, using a higher dose of this medicine is not recommended.
