Ácido Valpróico Ratiopharm

Ácido Valpróico Ratiopharm Uses, Dosage, Side Effects, Food Interaction and all others data.

Ácido Valpróico Ratiopharm shows antiepileptic properties in various types of seizures. The exact mechanism of Ácido Valpróico Ratiopharm is not yet established. However it is suggested that its activity is related to increased brain levels of Gama Amino Butyric Acid (GABA).

Ácido Valpróico Ratiopharm
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ácido Valpróico Ratiopharm
Generic	Sodium Valproate
Type
Therapeutic Class	Primary anti-epileptic drugs
Manufacturer	Ratiopharm - Comércio e Indústria de Produtos Farmacêuticos, Lda
Available Country	Portugal
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ácido Valpróico Ratiopharm is used for -

Epilepsy: All types of epilepsy such as Absence seizure, Myoclonic seizure, Tonic-clonic seizure, Atonic, Mixed, simple or generalized, Secondary generalized seizure etc.
Mania: For the treatment of manic episodes of bipolar disorders.
Other: As an alternative treatment for febrile convulsion & migraine prophylaxis.

Dosage

Ácido Valpróico Ratiopharm dosage

Oral:

Adults:

Initial: 600 mg/day in 2 divided doses, preferably after food. Dose may be increased by 200mg/day at 3 days interval to a maximum of 2.5 gm daily in divided doses until control of seizure is achieved.
Maintenance dose: Usually 1-2 gm daily (20-30 mg/kg daily).

Children (up to 20 kg):

Initial: 20 mg/kg daily in divided doses. Dose may be increased in severe cases with proper monitoring of plasma concentration.

Children (over 20 kg):

Initial: 400 mg/ day (irrespective of weight). Dose may be increased by 20-30 mg/ kg if required to achieve control.

Injection:

Ácido Valpróico Ratiopharm is for intravenous use only. Use of Ácido Valpróico Ratiopharm for periods of more than 14 days has not been studied. Patients should be switched to oral valproate products as soon as it is clinically feasible.

Ácido Valpróico Ratiopharm should be administered as a 60 minute infusion (but not more than 20 mg/min) with the same frequency as the oral products, although plasma concentration monitoring and dosage adjustments may be necessary.

In one clinical safety study, approximately 90 patients withepilepsyand with no measurable plasma levels of valproate were given single infusions of Ácido Valpróico Ratiopharm (up to 15 mg/kg and mean dose of 1184 mg) over 5-10 minutes (1.5-3.0 mg/kg/min). Patients generally tolerated the more rapid infusions well. This study was not designed to assess the effectiveness of these regimens.

Side Effects

Gastric irritation, nausea, ataxia & tremor; hyperammonaemia, increased appetite & weight gain; transient hair loss, oedema, thrombocytopenia, and inhibition of platelet aggregation, impaired hepatic function leading rarely to fetal hepatic failure; rashes; sedation; rarely lethargy and confusion and also increased alertness; rarely pancreatitis, leucopenia, pancytopenia, red cell hypoplasia, fibrinogen reduction; irregular periods, amenorrhoea, gynaecomastia, toxic epidermal necrolysis, hearing loss, Fancoli's syndrome, dementia, Steven's-Johnson syndrome, and vasculitis have also been reported.

Precaution

Liver function should be monitored before therapy and during first six months, especially in those patients who seem most at risk. Blood tests are recommended before surgery. Renal impaired patients, pregnant and brest feeding mother should be specially cared. Valproate is eliminated mainly through the kidney, partly in the form of ketone bodies which may lead to false statement in urine ketone test. Sudden withdrawal of therapy should be avoided

Interaction

Ácido Valpróico Ratiopharm is a non specific inhibitor of drug metabolism. Phenobarbital, Phenytoin, Warfarin, Aspirin etc. interacts with Ácido Valpróico Ratiopharm.

Pregnancy & Breastfeeding use

Ácido Valpróico Ratiopharm crosses the placenta in humans which may lead to neural tube defects such as anencephaly and spina bifida if exposed in the first trimester. Ácido Valpróico Ratiopharm may excrete in breast milk. So treatment with Ácido Valpróico Ratiopharm may cause harm to new born baby.

Contraindication

Ácido Valpróico Ratiopharm is contra-indicated in patients with known hypersensitivity of Ácido Valpróico Ratiopharm, personal or family history of severe active liver disease, hepatic dysfunction, porphyria and known urea cycle disorder.

Storage Condition

Syrup: Store below 30° C, protected from light.

Tablet: Store below 30° C, protected from light. Keep all medicines out of the reach of children.

Innovators Monograph

You find simplified version here Ácido Valpróico Ratiopharm

FAQ

What is Ácido Valpróico Ratiopharm used for?

Ácido Valpróico Ratiopharm used to treat epilepsy and bipolar disorder. It's occasionally used to prevent migraine headaches. This medicine is only available on prescription.

How safe is Ácido Valpróico Ratiopharm?

Many people can take Ácido Valpróico Ratiopharm safely for many months or years. However, there are potential side effects that can happen over a long time. Long-term treatment with Ácido Valpróico Ratiopharm can cause osteoporosis and osteopenia.

How long does it take for sodium valproate to work?

Ácido Valpróico Ratiopharm may take several days to show an initial effect and in some cases may take from two to six weeks for maximum effect. Treatment is started with low doses and may be increased over a couple of weeks according to your child's response.

What are the common side effects of Ácido Valpróico Ratiopharm?

The common side effects of Ácido Valpróico Ratiopharm are include:

stomach pain, feeling or being sick
diarrhoea
dry or sore mouth, or swollen gums
shakes (tremors) in a part of your body, or unusual eye movements
feeling tired or sleepy
headache
weight gain
thinning hair, or changes to the colour or texture of your hair
irregular or delayed periods

How to take Ácido Valpróico Ratiopharm?

Ácido Valpróico Ratiopharm comes as slow release (prolonged or sustained release) tablets, capsules and granules, gastro-resistant tablets, crushable tablets, and as a liquid.
Slow release medicine passes into your body gradually.

When is the best time to take Ácido Valpróico Ratiopharm?

You can take Ácido Valpróico Ratiopharm with or without food, but it's best to stick to the same way each time. Do not take it with food some days and without food on other days.

How often can I take Ácido Valpróico Ratiopharm?

If you're taking Ácido Valpróico Ratiopharm once a day, you can choose a time that suits you. Just try to keep to the same time every day.
If you're taking Ácido Valpróico Ratiopharm twice a day, try to leave a gap of 10 to 12 hours between doses. For example you could take your first dose in the morning (between 7am and 8am) and your second dose in the evening (between 7pm and 8pm).

Is Ácido Valpróico Ratiopharm safe during pregnancy?

Ácido Valpróico Ratiopharm is not recommended in pregnancy, as it can cause birth defects and problems with your baby's learning and behaviour.
If there's a chance you could become pregnant while taking this medicine, your doctor will put you on Prevent, the Ácido Valpróico Ratiopharm prevention programme.

Is Ácido Valpróico Ratiopharm safe during breastfeeding?

If your doctor or health visitor says your baby is healthy you can take Ácido Valpróico Ratiopharm while breastfeeding.
Ácido Valpróico Ratiopharm passes into breast milk in small amounts but it's unlikely to harm your baby so you can continue breastfeeding if your doctor says you need to take it.

How long will I take Ácido Valpróico Ratiopharm?

Once your condition is under control, you'll usually need to keep taking Ácido Valpróico Ratiopharm for many years.

Is Ácido Valpróico Ratiopharm safe to take it for a long time?

Many people can take Ácido Valpróico Ratiopharm safely for many months or years.
However, there are potential side effects that can happen over a long time. Long-term treatment with Ácido Valpróico Ratiopharm can cause osteoporosis and osteopenia.

What will happen when I come off Ácido Valpróico Ratiopharm?

Do not stop taking Ácido Valpróico Ratiopharm suddenly, unless your doctor tells you to.
You're unlikely to get any extra symptoms when you stop taking this medicine. However, if you're taking Ácido Valpróico Ratiopharm for epilepsy, it's possible that you'll get seizures again once you stop taking it. You can prevent these withdrawal seizures by reducing your dose of Ácido Valpróico Ratiopharm gradually.

Can I drink alcohol with Ácido Valpróico Ratiopharm?

Drinking alcohol while taking Ácido Valpróico Ratiopharm may make you feel sleepy or tired. It's best to stop drinking alcohol during the first few days, until you see how the medicine affects you.

Will Ácido Valpróico Ratiopharm affect my fertility?

Ácido Valpróico Ratiopharm can reduce fertility in both men and women. Once you stop taking this medicine, your fertility will return.In men Ácido Valpróico Ratiopharm has been reported to cause infertility.

Will Ácido Valpróico Ratiopharm affect my contraception?

Ácido Valpróico Ratiopharm does not affect any type of contraception, including the combined pill and emergency contraception.If there's a chance you could become pregnant while taking Ácido Valpróico Ratiopharm you must use contraception. Your doctor will put you on Prevent, the valproate pregnancy prevention programme.

Can I drive after taking Ácido Valpróico Ratiopharm?

You may feel sleepy, tired or dizzy when you first start taking Ácido Valpróico Ratiopharm. This may also happen if your dose has increased. If you're affected, do not drive or ride a bike until you feel more alert.

Can I take too much dose of Ácido Valpróico Ratiopharm?

Taking too much Ácido Valpróico Ratiopharm can lead to symptoms such as: feeling or being sick, headaches or feeling dizzy,muscle weakness.

What happen If I missed Ácido Valpróico Ratiopharm?

If you've missed a dose, what you do next depends on whether you usually take your medicine once or twice a day. If you take Ácido Valpróico Ratiopharm once a day ,take the forgotten dose as soon as you remember unless it's within a few hours of the next dose.