Primary mediastinal large B-cell lymphomas
Primary Mediastinal Large B-Cell Lymphomas
Primary mediastinal large B-cell lymphomas are a type of non-Hodgkin's lymphoma, which is a type of cancer that affects the lymphatic system. These lymphomas originate in the mediastinum, the area in the chest between the lungs. Primary mediastinal large B-cell lymphomas account for 3-5% of all non-Hodgkin's lymphomas and are most common in young people, particularly women in their teens and early twenties.
Symptoms of Primary Mediastinal Large B-Cell Lymphoma
Patients with primary mediastinal large B-cell lymphoma often experience no symptoms. If they do, the most common symptom is a swelling in the neck, which can be accompanied by other symptoms such as fever, night sweats, shortness of breath, weight loss, and fatigue.
How is Primary Mediastinal Large B-Cell Lymphomas Diagnosed?
The diagnosis of primary mediastinal large B-cell lymphoma is typically made through a combination of physical examination, imaging, and laboratory tests. Imaging tests such as chest X-ray, CT scan, and MRI are often used to detect enlarged lymph nodes or masses in the chest. A biopsy of the affected area may also be done in order to confirm the diagnosis.
Treatment of Primary Mediastinal Large B-Cell Lymphoma
The treatment of primary mediastinal large B-cell lymphoma depends on the stage and extent of the cancer and the patient's overall health. Common treatments include:
- Chemotherapy
- Radiation therapy
- Stem cell transplant
- Targeted therapies
The prognosis of primary mediastinal large B-cell lymphoma depends on the stage of the cancer and how quickly it responds to treatment. Most patients can achieve remission with appropriate treatment.