(+/-)-molindone

(+/-)-molindone Uses, Dosage, Side Effects, Food Interaction and all others data.

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. (+/-)-molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)

(+/-)-molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones, or the thioxanthenes. (+/-)-molindone has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, molindone antagonizes the depression caused by the tranquilizing agent tetrabenazine.

(+/-)-molindone
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	(+/-)-molindone
Availability	Discontinued
Generic	Molindone
Molindone Other Names	(+/-)-molindone, Molindona, Molindone, Molindonum
Related Drugs	quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine
Type
Formula	C₁₆H₂₄N₂O₂
Weight	Average: 276.374 Monoisotopic: 276.183778022
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

(+/-)-molindone is an antipsychotic used to treat schizophrenia.

(+/-)-molindone is used for the management of the manifestations of psychotic disorders.

(+/-)-molindone is also used to associated treatment for these conditions: Schizophrenia

How (+/-)-molindone works

The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally induced by excessive dopamine stimulation, such as those typically seen in manifestations of psychotic disorders.

Food Interaction

Avoid alcohol. Severe CNS depression, which can be caused by alcohol, is a contraindication for molindone hydrochloride therapy.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

(+/-)-molindone Drug Interaction

Major: clozapine, clozapineModerate: aripiprazole, aripiprazole, lorazepam, lorazepam, citalopram, citalopram, duloxetine, duloxetine, iloperidone, iloperidone, ziprasidone, ziprasidone, haloperidol, haloperidol, paliperidone, paliperidone, lurasidone, lurasidone

(+/-)-molindone Disease Interaction

Major: dementia, CNS depression/coma, related psychosis, previous neuroleptic malignant syndrome (NMS), seizure disorders, acute alcohol intoxication, cardiovascular disease, CNS depression, NMS, tardive dyskinesiaModerate: seizure, hyperprolactinemia/breast cancer, intestinal obstruction, neutropenia, anticholinergic effects, dehydration, hyperprolactinemia, liver disease, parkinsonism

Elimination Route

Rapidly absorbed from the gastrointestinal tract following oral administration.

Elimination Route

Human metabolic studies show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites with less than 2-3% unmetabolized molindone being excreted in urine and feces.