(+/-)-pirbuterol
(+/-)-pirbuterol Uses, Dosage, Side Effects, Food Interaction and all others data.
(+/-)-pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
(+/-)-pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
| Trade Name | (+/-)-pirbuterol |
| Availability | Discontinued |
| Generic | Pirbuterol |
| Pirbuterol Other Names | (+/-)-pirbuterol, Pirbuterol, Pirbuterolum |
| Related Drugs | Dupixent, Xolair, ProAir Digihaler, albuterol, azithromycin, dexamethasone, methylprednisolone, Symbicort, Zithromax, Breo Ellipta |
| Type | |
| Formula | C12H20N2O3 |
| Weight | Average: 240.2988 Monoisotopic: 240.147392516 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(+/-)-pirbuterol is a beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma.
For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
How (+/-)-pirbuterol works
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Toxicity
As with all sympathomimetic aerosol medication, cardiac arrest and even death may be associated with abuse of pirbuterol.
(+/-)-pirbuterol Hypertension interaction
[Moderate] Adrenergic bronchodilators can stimulate cardiovascular beta- 1 and beta- 2 receptors, resulting in adverse effects such as tachycardia, palpitation, peripheral vasodilation, blood pressure changes, and ECG changes (e.g., flattening of the T wave; prolongation of the QT interval; ST segment depression).
Direct stimulation of cardiac tissues is mediated by beta- 1 receptors and thus less likely to occur with beta-2-selective agents such as albuterol.
However, beta-2-selectivity is not absolute and can be lost with larger doses.
High dosages of these agents have been associated with precipitation or aggravation of angina, myocardial ischemia, and cardiac arrhythmias.
Therapy with adrenergic bronchodilators should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, and The recommended dosages should not be exceeded.
(+/-)-pirbuterol Drug Interaction
Moderate: fluticasone / salmeterol, racepinephrine, duloxetine, escitalopramMinor: mometasoneUnknown: fexofenadine, lubiprostone, aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide, aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide, lorazepam, amoxicillin / clavulanate, irbesartan, acamprosate, Allergy , loratadine, docusate, bisacodyl, acetaminophen, tolterodine, glucose
(+/-)-pirbuterol Disease Interaction
Half Life
2 hours.
Innovators Monograph
You find simplified version here (+/-)-pirbuterol
