1-Menthyl salicylate
1-Menthyl salicylate Uses, Dosage, Side Effects, Food Interaction and all others data.
1-Menthyl salicylate is an ester of menthol and salicylic acid .
This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) .
Menthol and methyl salicylate are known as counterirritants. They work by causing the skin to feel cool and then warm. Used together, they provide symptomatic relief for mild to moderate muscular and joint aches and pains, muscle cramps, shoulder aches and stiff neck..
| Trade Name | 1-Menthyl salicylate |
| Generic | Menthyl salicylate |
| Menthyl salicylate Other Names | 1-Menthyl salicylate |
| Type | |
| Formula | C17H24O3 |
| Weight | Average: 276.376 Monoisotopic: 276.172544633 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the temporary relief of pain associated with rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and fibrositis .
1-Menthyl salicylate is also used to associated treatment for these conditions: Pain
How 1-Menthyl salicylate works
Menthol dilates the blood vessels causing a sensation of coldness, followed by an analgesic effect. Menthol also acts as a penetration enhancer, increasing the penetration of drugs when applied on the skin, to give a faster onset of action .
Methyl salicylate is a salicylic acid derivative, and when combined with menthol, produces menthyl salicylate .
Salicylates inhibit cyclooxygenase, thereby reducing the formation of prostaglandins, and cause platelet dysfunction Methyl salicylate is used topically as a counter-irritant. Upon application, it is absorbed through the skin and is applied for the relief of pain in rheumatic conditions and painful muscle or joints .
The menthol dilates blood vessels, why the salicylate portion provides a topical anesthetic and analgesic action on the affected area. The cooling and warning action may interfere with the transmission of pain signals through nerves .
Toxicity
Salicylate intoxication may occur after ingestion or topical application of menthyl salicylate. Mild chronic salicylate intoxication, also known as salicylism, normally occurs only after repeated use of large doses.
Salicylism can also occur following the excessive topical application of salicylates. Symptoms of toxicity include dizziness, tinnitus, deafness, sweating, nausea and vomiting, headache, and confusion, and may be controlled by reducing the dosage .
Symptoms of more severe intoxication or of acute poisoning following overdose include hyperventilation, fever, restlessness, ketosis, and respiratory alkalosis and metabolic acidosis. Depression of the CNS may lead to coma, cardiovascular collapse and respiratory failure may also result .
Food Interaction
No interactions found.Elimination Route
May be absorbed through intact skin. The absorption of topical salicylates is proportional to the surface area exposed, the duration of exposure, concentration and skin integrity. Absorption characteristics of salicylates vary with the dose, formulation, and route of administration. Percutaneous absorption is enhanced by exercise, heat, occlusion, or disruption of the integrity of the skin or application to large areas of skin. Both the rate and extent of absorption increases after continuous application, increasing its bioavailability .
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