4-Demethylpenclomedine

4-Demethylpenclomedine Uses, Dosage, Side Effects, Food Interaction and all others data.

Table Of contents

• 4-Demethylpenclomedine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	4-Demethylpenclomedine
Generic	4-O-Demethylpenclomedine
4-O-Demethylpenclomedine Other Names	4-Demethylpenclomedine, 4-Dm-pen, 4-Dmpen, DM-PEN, DMPEN
Type
Formula	C7H4Cl5NO2
Weight	Average: 311.36 Monoisotopic: 308.8684669
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in solid tumors.

How 4-Demethylpenclomedine works

DMPEN (4,o-demethylpenclomedine) is the highly reactive principal alkylating metabolite of Penclomedine (PEN), a multichlorinated alpha-picoline derivative. DM-PEN’s proposed mechanism of action begins with activation by free radical formation in the liver, where it is then transported to tumor cells via the circulation system. The free radical moiety forms an adduct with DNA, and interstrand crosslinking occurs through the 5-chloro moiety. The 5-chloro moiety is then activated by keto-enol tautomerism, producing the alkylating group, an alpha-haloketo function.

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