4-hydroxytamoxifen
4-hydroxytamoxifen Uses, Dosage, Side Effects, Food Interaction and all others data.
4-hydroxytamoxifen (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and gynecomastia. TamoGel is formulated using Enhanced Hydroalcoholic Gel (EHG) Technology. This technology enables percutaneous delivery of drugs that cannot be delivered orally. It is being developed by Ascent Therapeutics.
| Trade Name | 4-hydroxytamoxifen |
| Generic | Afimoxifene |
| Afimoxifene Other Names | 4-hydroxytamoxifen, 4-monohydroxytamoxifen, 4-OHT, Afimoxifene |
| Type | |
| Formula | C26H29NO2 |
| Weight | Average: 387.514 Monoisotopic: 387.219829177 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
How 4-hydroxytamoxifen works
4-hydroxytamoxifen binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes.
Elimination Route
Absorbed following topical application.
Innovators Monograph
You find simplified version here 4-hydroxytamoxifen
