ACE2 CAR-NK Cell
ACE2 CAR-NK Cell Uses, Dosage, Side Effects, Food Interaction and all others data.
These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling moieties. First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being engineered onto natural killer (NK) cells due to lower potential for graft-versus-host disease and cytokine release syndrome. The IL-15 superagonist increases the activity of NK cells and improves their target cytotoxicity. The GM-CSF acts as a neutralizer for the CAR-T cell-mediated cytokine release and neurotoxicity. The transmembrane NKG2D and intracellular 2B4 domains are required for optimal NK signalling and subsequent cell-mediated cytotoxicity. The ACE2 is a receptor for SARS-Cov-2, binding to the S-protein of the viral envelope and competitively inhibiting SARS-Cov-2 infection of type II alveolar epithelial cells.
| Trade Name | ACE2 CAR-NK Cell |
| Generic | NKG2D-ACE2 CAR-NK Cell |
| NKG2D-ACE2 CAR-NK Cell Other Names | ACE2 CAR-Natural Killer Cell, ACE2 CAR-NK Cell, NKG2D CAR-Natural Killer Cell, NKG2D CAR-NK Cell, NKG2D-ACE2 CAR-Natural Killer Cell |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
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| Last Updated: | September 19, 2023 at 7:00 am |
How ACE2 CAR-NK Cell works
NK cells modified by CARs play a role in targeted immunotherapy without subsequent cytokine release syndrome or neurotoxicity as these effects are mediated through GM-CSF neutralization. The NKG2D-ACE2 CAR-NK cells secreting super IL15 superagonist and GM-CSF neutralizing scFv is thought to act synergistically to target and kill cells infected with SARS-Cov-2 without widespread cytokine release and inflammation.
Innovators Monograph
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