Acepromazinum
Acepromazinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Acepromazinum is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Acepromazinum is one of the phenothiazine derivative psychotropic drugs. Acepromazinum has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazinum has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
Trade Name | Acepromazinum |
Generic | Acepromazine |
Acepromazine Other Names | Acepromazina, Acepromazine, Acepromazinum, Acetazine, Acetopromazine, Acetylpromazine |
Type | |
Formula | C19H22N2OS |
Weight | Average: 326.456 Monoisotopic: 326.145284026 |
Groups | Experimental, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acepromazinum was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazinum is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
How Acepromazinum works
Acepromazinum acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Toxicity
Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Food Interaction
- Avoid alcohol.
- Take with food. Food reduces irritation.
Half Life
3 hours in horses.
Innovators Monograph
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