Acetarsol
Acetarsol Uses, Dosage, Side Effects, Food Interaction and all others data.
Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties. It was first discovered in 1921 by Ernest Fourneau at the Pasteur Institute. It was developed by Neolab Inc, and approved by Health Canada as an antifungal on December 31, 1964. It has been canceled and withdrawn from the market since August 12, 1997.
Some reports indicate a certain infection remission with the use of acetarsol but this reports also demonstrate the absorption of systemic arsenic which can be physiologically dangerous.
| Trade Name | Acetarsol |
| Generic | Acetarsol |
| Acetarsol Other Names | Acetarsol |
| Type | |
| Formula | C8H10AsNO5 |
| Weight | Average: 275.0903 Monoisotopic: 274.977493852 |
| Protein binding | This pharmacokinetic property was not addressed. |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acetarsol is an anti infective used to treat a wide variety of infections in the body.
Acetarsol has been used for the treatment of different diseases such as syphilis, amoebiasis, yaws, trypanosomiasis, and malaria. Acetarsol was used commonly for the treatment of vaginitis due to Trichomonas vaginalis and Candida albicans. When orally administered, acetarsol can be used for the treatment of intestinal amoebiasis and in the form of suppositories it has been researched for the treatment of proctitis.
Protozoan infections are parasitic diseases characterized to be caused by organisms classified in the kingdom Protozoa which is formed by a great diversity of organisms.
Acetarsol is also used to associated treatment for these conditions: Amoebiasis, Vaginitis caused by Trichomonas Vaginalis, candida albicans
How Acetarsol works
The mechanism of action of acetarsol is not well known but it is thought to bind to protein-containing sulfhydryl groups located in the infective microorganism and to form a lethal As-S bond. The formation of this bond impairs the protein to function and it eventually kills the microorganism.
Toxicity
The administration of inorganic arsenic is highly carcinogenic and thus acetarsol if thought to be dangerous when absorbed. Some reports indicate that acetarsol can produce effects in the eyes such as optic neuritis and optic atrophy.
Volume of Distribution
This pharmacokinetic property was not addressed.
Elimination Route
The absorption seems to be very minimal but there are reports of allergic reactions after vaginal administration of acetarsol.
Half Life
This pharmacokinetic property was not addressed.
Clearance
This pharmacokinetic property was not addressed.
Elimination Route
The arsenic found in acetarsol is excreted mainly in the urine. The level of arsenic after acetarsol administration almost reaches the toxic range in urine.
Innovators Monograph
You find simplified version here Acetarsol
