Acetarsol

Acetarsol Uses, Dosage, Side Effects, Food Interaction and all others data.

Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties. It was first discovered in 1921 by Ernest Fourneau at the Pasteur Institute. It was developed by Neolab Inc, and approved by Health Canada as an antifungal on December 31, 1964. It has been canceled and withdrawn from the market since August 12, 1997.

Some reports indicate a certain infection remission with the use of acetarsol but this reports also demonstrate the absorption of systemic arsenic which can be physiologically dangerous.

Trade Name Acetarsol
Generic Acetarsol
Acetarsol Other Names Acetarsol
Type
Formula C8H10AsNO5
Weight Average: 275.0903
Monoisotopic: 274.977493852
Protein binding

This pharmacokinetic property was not addressed.

Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Acetarsol
Acetarsol

Uses

Acetarsol is an anti infective used to treat a wide variety of infections in the body.

Acetarsol has been used for the treatment of different diseases such as syphilis, amoebiasis, yaws, trypanosomiasis, and malaria. Acetarsol was used commonly for the treatment of vaginitis due to Trichomonas vaginalis and Candida albicans. When orally administered, acetarsol can be used for the treatment of intestinal amoebiasis and in the form of suppositories it has been researched for the treatment of proctitis.

Protozoan infections are parasitic diseases characterized to be caused by organisms classified in the kingdom Protozoa which is formed by a great diversity of organisms.

Acetarsol is also used to associated treatment for these conditions: Amoebiasis, Vaginitis caused by Trichomonas Vaginalis, candida albicans

How Acetarsol works

The mechanism of action of acetarsol is not well known but it is thought to bind to protein-containing sulfhydryl groups located in the infective microorganism and to form a lethal As-S bond. The formation of this bond impairs the protein to function and it eventually kills the microorganism.

Toxicity

The administration of inorganic arsenic is highly carcinogenic and thus acetarsol if thought to be dangerous when absorbed. Some reports indicate that acetarsol can produce effects in the eyes such as optic neuritis and optic atrophy.

Volume of Distribution

This pharmacokinetic property was not addressed.

Elimination Route

The absorption seems to be very minimal but there are reports of allergic reactions after vaginal administration of acetarsol.

Half Life

This pharmacokinetic property was not addressed.

Clearance

This pharmacokinetic property was not addressed.

Elimination Route

The arsenic found in acetarsol is excreted mainly in the urine. The level of arsenic after acetarsol administration almost reaches the toxic range in urine.

Innovators Monograph

You find simplified version here Acetarsol

*** Taking medicines without doctor's advice can cause long-term problems.
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