Acide Fusidique
Acide Fusidique Uses, Dosage, Side Effects, Food Interaction and all others data.
Fusidic acid is an antimicrobial agent that inhibits bacterial protein synthesis. Fusidic acid interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Fusidic acid is active against a wide range of gram-positive organisms. The sustained release formulation ensures prolonged contact with the conjunctival sac. Fusidic acid penetrates well into the aqueous humor.
Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.
| Trade Name | Acide Fusidique |
| Generic | Fusidic Acid |
| Fusidic Acid Other Names | Acide fusidique, Acido fusidico, Acidum fusidicum, Fucidate, Fucidin acid, Fusidate, Fusidic acid, Fusidine, Ramycin |
| Type | |
| Formula | C31H48O6 |
| Weight | Average: 516.7092 Monoisotopic: 516.345089268 |
| Protein binding | 97 to 99% |
| Groups | Approved, Investigational |
| Therapeutic Class | Miscellaneous Antibiotics |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acide Fusidique is used for the topical treatment of superficial bacterial infections of the eye and its adnexa. These may include - bacterial conjunctivitis, blepharoconjunctivitis, blepharitis, sty and keratitis. It may also be used for the management of corneal and conjunctival abrasions and foreign body injuries.
Acide Fusidique is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Eye and eyelid infections, Fungal skin infection, Skin Infections caused by Corynebacterium minutissimum infection, Skin Infections caused by Staphylococcus Aureus, Skin Infections caused by Streptococcus Infection, Skin Infections, Bacterial, Stye, Cutaneous dermatophyte infection, Eczematous rash, Mild Atopic dermatitis, Mild Dermatitis caused by Staphylococcus aureusis, Moderate Atopic dermatitis, Moderate Dermatitis caused by Staphylococcus aureusis, Ocular bacterial infections, Susceptible Bacterial Infections
How Acide Fusidique works
Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Dosage
Acide Fusidique dosage
Adults and children (≥ 2 years): Instill one drop in the affected eye(s) twice daily for 7 days. Treatment should be continued for at least 48 hours after the eye returns to normal.
Side Effects
Fusidic acid is generally associated with very few adverse effects. The most frequently reported treatment-related side-effect is slight stinging or irritation.
Precaution
- For ophthalmic use only
- To avoid possible contamination of the drops, do not touch the tube nozzle or to any surface
- Do not wear contact lenses during the treatment
- If more than one topical eye drug is being used, the drugs should be administered at least five (5) minutes interval between applications
Interaction
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Food Interaction
- Take with food. Food reduces irritation.
Elimination Route
Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Half Life
Approximately 5 to 6 hours in adults.
Pregnancy & Breastfeeding use
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Fusidic acid should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Use in lactation: It is not clear if enough medication from the eye drop would pass into breast milk. Caution should be exercised while giving this eye drops to a nursing mother
Contraindication
Fusidic acid viscous eye drops is contraindicated in patients who are hypersensitive to any component of Acide Fusidique (Eye Drops).
Special Warning
Use in children: Safety & effectiveness in children below the age of 2 years have not been established.
Storage Condition
Store between 2-25°C. Discard 1 mth after opening.
Innovators Monograph
You find simplified version here Acide Fusidique
FAQ
What is Acide Fusidique used for?
Acide Fusidique is an antibiotic that is often used topically in creams and eyedrops but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently. Acide Fusidique cream should be used on the skin. The cream is used for the local treatment of skin infections caused by bacteria that are sensitive to Acide Fusidique such as impetigo (a weeping, crusty and swollen patch of skin), folliculitis, sycosis barbae, paronychia, erythrasma.
How safe is Acide Fusidique?
There is inadequate evidence of safety in human pregnancy. Animal studies and many years of clinical experience suggest that Acide Fusidique is devoid of teratogenic effects (birth defects), but Acide Fusidique can cross the placental barrier.
How does Acide Fusidique work?
Acide Fusidique works by stopping the growth of the germs causing the infection.
What are the common side effects of Acide Fusidique?
Common side effects of Acide Fusidique are include:
- Skin rashes.
- Skin itching.
- Pain, stinging, burning sensation or redness of skin on application.
- Contact dermatitis.
Is Acide Fusidique safe during pregnancy?
It's safe to use Acide Fusidique cream, ointment or eye drops while you're pregnant. Very little of the medicine gets to your baby, and the small amount that does will not harm them.
Is Acide Fusidique safe during breastfeeding?
Acide Fusidique cream can be used during breastfeeding but it is recommended to avoid applying Acide Fusidique cream on the breast.
Is Acide Fusidique cream safe for babies?
Using Acide Fusidique cream topically and breast-feeding is unlikely to harm your baby.
Can I use Acide Fusidique daily?
Apply a small amount to the affected area 2 to 3 times daily for 7 to 14 days. If your doctor has directed you to cover the lesion with a gauze dressing, you may be directed to apply the medication only 1 or 2 times daily.
How long does Acide Fusidique stay in my system?
The usual treatment time is up to 2 weeks. You should notice your skin improve after just a few days of using the cream. If there is no improvement after 7 days you should stop using the cream and go back to your doctor.
Is Acide Fusidique good for acne?
Topical Acide Fusidique is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Acide Fusidique is often partially effective at improving acne symptoms.
How often can I use Acide Fusidique ?
It's usual to put on Acide Fusidique cream or ointment 3 or 4 times a day.
What happens if I miss a dose of Acide Fusidique?
If you forget to apply this Acide Fusidique, apply it as soon as you remember. If it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Who should not take Acide Fusidique?
Acide Fusidique topical products should not be used If you have allergic to Acide Fusidique and its salts or to any of the ingredients of this medication.
When can I stop using Acide Fusidique ?
Treatment should be stopped after 7 days if your skin has not improved after using Acide Fusidique cream.
What happen if I take too much Acide Fusidique?
If you apply too much Acide Fusidique cream, it is unlikely to cause any harm. However, if you notice any effect or are worried, contact your doctor or pharmacist.
Is Acide Fusidique a strong antibiotic?
Acide Fusidique is a steroidal antibiotic and the only marketed member of the fusidane class.
Is Acide Fusidique an antifungal?
Acide Fusidique showed that compound 7 had strongest antifungal activity.
Is Acide Fusidique good for pimples?
Topical Acide Fusidique is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Acide Fusidique is often partially effective at improving pimples.
Can Acide Fusidique be used for cold sores?
No, Acide Fusidique is inapplicable on cold sores.
Is Acide Fusidique cream good for cuts?
Acide Fusidique is made to be put directly on skin and wounds.
