Адеметионина 1,4-бутандисульфонат

Адеметионина 1,4-бутандисульфонат Uses, Dosage, Side Effects, Food Interaction and all others data.

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver.

Адеметионина 1,4-бутандисульфонат
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Адеметионина 1,4-бутандисульфонат
Generic	Ademetionine
Ademetionine Other Names	Ademetionine, AdoMet, L-S-Adenosylmethionine, S-Adenosylmethionine, SAM-e, SAMe
Type
Formula	C₁₅H₂₂N₆O₅S
Weight	Average: 398.44 Monoisotopic: 398.137239006
Groups	Approved, Investigational, Nutraceutical
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	September 19, 2023 at 7:00 am

Uses

S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.

Адеметионина 1,4-бутандисульфонат is also used to associated treatment for these conditions: Fatigue, Intrahepatic, Cholestasis, Major Depressive Disorder (MDD)

How Адеметионина 1,4-бутандисульфонат works

S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.

Toxicity

Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.

Elimination Route

S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.

Innovators Monograph

You find simplified version here Адеметионина 1,4-бутандисульфонат

FAQ

How safe is Адеметионина 1,4-бутандисульфонат?

Адеметионина 1,4-бутандисульфонат is used in the treatment of liver disease. It is used in liver condition associated with reduced bile formation. Адеметионина 1,4-бутандисульфонат protects the liver cells from toxins and helps the liver to perform its normal function.

How safe is Адеметионина 1,4-бутандисульфонат?

Адеметионина 1,4-бутандисульфонат is considered safe for most adults. However, it can worsen symptoms in patients with certain disorders, such as bipolar disorder or Parkinson's disease.

What are the common side effects of Адеметионина 1,4-бутандисульфонат?

Common side effects of Адеметионина 1,4-бутандисульфонат are include:

gas
constipation
diarrhea
vomiting
dry mouth
headache
mild insomnia
anorexia
sweating
dizziness
nervousness
skin rashes
serotonin syndrome

Is Адеметионина 1,4-бутандисульфонат safe during pregnancy?

Pregnant women should not take Адеметионина 1,4-бутандисульфонат.

Is Адеметионина 1,4-бутандисульфонат safe during breastfeeding?

Адеметионина 1,4-бутандисульфонат is considered safe for most adults.

Can I drink alcohol with Адеметионина 1,4-бутандисульфонат?

Avoid consumption of alcohol while taking Адеметионина 1,4-бутандисульфонат as it may cause increased dizziness and liver damage.

How do I take Адеметионина 1,4-бутандисульфонат?

Адеметионина 1,4-бутандисульфонат tablets should be swallowed whole. For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.

How long does Адеметионина 1,4-бутандисульфонат take to work?

The effects of IV or IM treatment are evident after 1-2 weeks of therapy, whereas, oral treatment is suitable for maintenance therapy.

What is the common side effects of Адеметионина 1,4-бутандисульфонат?

The half-life is about 100 minutes.

Can I take Адеметионина 1,4-бутандисульфонат for a long time?

You are advised to take Адеметионина 1,4-бутандисульфонат for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as abdominal discomfort, abdominal pain, diarrhea, nausea, dizziness, insomnia.

Can I stop taking Адеметионина 1,4-бутандисульфонат?

Do not discontinue Адеметионина 1,4-бутандисульфонат without consulting your doctor. To treat your condition effectually, continue taking Адеметионина 1,4-бутандисульфонат for as long as prescribed.

Who should not take Адеметионина 1,4-бутандисульфонат?

Do not take Адеметионина 1,4-бутандисульфонат if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, inflammation of gall bladder and bile ducts, narrowing or blockage bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Адеметионина 1,4-бутандисульфонат to make up the missed dose.

Can I overdose on Адеметионина 1,4-бутандисульфонат?

Cases of overdose with Адеметионина 1,4-бутандисульфонат appear to be rare. Physicians should contact local poison control centers. In general, patients should be monitored and supportive care provided. Known hypersensitivity to ademetionine or to any of the excipients of Heptral.

Can Адеметионина 1,4-бутандисульфонат affect my heart?

Side effects can include heart problems, shivering, and anxiety.

Can Адеметионина 1,4-бутандисульфонат affects my liver?

Адеметионина 1,4-бутандисульфонат can be given to children with caution if prescribed by the doctor. Avoid consuming alcohol along with Адеметионина 1,4-бутандисульфонат as it could lead to increased drowsiness and liver damage.

Does Адеметионина 1,4-бутандисульфонат cause weight loss?

Адеметионина 1,4-бутандисульфонат works more rapidly and does not cause weight gain, sexual dysfunction, sedation, or cognitive interference.

Is Адеметионина 1,4-бутандисульфонат safe for kidneys?

The established nephroprotective properties of Адеметионина 1,4-бутандисульфонат that are potentiated by Meldonium are probably due to the ability of these Адеметионина 1,4-бутандисульфонат to eliminate endothelial dysfunction, improve microcirculation, and prevent the progression of kidney fibrosis.