Advantage 24
Advantage 24 Uses, Dosage, Side Effects, Food Interaction and all others data.
Advantage 24 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.
| Trade Name | Advantage 24 |
| Generic | Nonoxynol-9 |
| Nonoxynol-9 Other Names | Nonoxynol 9, PEG-9 nonyl phenyl ether, Tergitol NP-9 |
| Type | |
| Formula | C33H60O10 |
| Weight | Average: 616.8235 Monoisotopic: 616.41864814 |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Advantage 24 is a vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants. It is also used in conjuction with other methods of contraception, including condoms, cervical caps and diaphragms.
Advantage 24 is also used to associated treatment for these conditions: Contraceptive sponge therapy
How Advantage 24 works
Advantage 24 interacts with the lipids in the membranes of the acrosome and the midpiece of the sperm. The sperm membranes are lysed; the acrosome, neck and midpiece of the spermatozoa are loosened and then detached which results in their immobilization and death.
Toxicity
The major drawback of nonoxynol-9 is its detergent-type action on epithelial cells and the normal vaginal flora. Detergent-type spermicides alter the vaginal flora, possibly leading to an increased risk of opportunistic infections. These are known to enhance the susceptibility of the epithelium of the lower genital tract to HIV and human papillomavirus infection. N-9 can cause vaginal irritation and allergic vaginitis as well as genital irritation in male partners.
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here Advantage 24
