Alefacept

Alefacept Uses, Dosage, Side Effects, Food Interaction and all others data.

Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.

Interferes with lymphocyte activation by specifically binding to the lymphocyte antigen, CD2, and inhibiting LFA-3/CD2 interaction. Activation of T lymphocytes involving the interaction between LFA-3 on antigen-presenting cells and CD2 on T lymphocytes plays a role in the pathophysiology of chronic plaque psoriasis. Also causes a reduction in subsets of CD2+ T lymphocytes as well as CD4+ and CD8+ T lymphocytes.

Table Of contents

• Alefacept
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Alefacept
Availability	Discontinued
Generic	Alefacept
Alefacept Other Names	Alefacept
Related Drugs	Humira, Otezla, Cosentyx, methotrexate, Enbrel, Remicade, Stelara, cyclosporine, infliximab
Type	Intramuscular
Formula	C2306H3594N610O694S26
Weight	51801.1 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Alefacept is a recombinant fusion protein that binds CD2 and is used treat moderate to severe plaque psoriasis.

As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis

How Alefacept works

Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen.

Toxicity

While it has been found to cross the placenta in monkeys, it is not yet known if it also diffuses into breast milk.

Alefacept Drug Interaction

Moderate: alprazolam, alprazolam, carboplatin, carboplatinUnknown: acetaminophen, acetaminophen, aspirin, aspirin, pseudoephedrine / triprolidine, pseudoephedrine / triprolidine, clotrimazole, clotrimazole, indium pentetate in-111, indium pentetate in-111

Elimination Route

Bioavailability after IM administration is 63%.

Half Life

~270 hours

Innovators Monograph

You find simplified version here Alefacept