Alferon N

Alferon N Uses, Dosage, Side Effects, Food Interaction and all others data.

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).

Alferon N upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.

Alferon N
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Alferon N
Generic	Interferon alfa-n3
Interferon alfa-n3 Other Names	Interferon alfa-n3
Weight	5000000intlunits/ml,
Type	Injectable solution
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Alferon N is a purified form of human interferon used to stimulate the innate antiviral response in the treatment of genital warts due to human papilloma virus.

For the intralesional treatment of refractory or recurring external condylomata acuminata.

Alferon N is also used to associated treatment for these conditions: Refractory Condylomata acuminata of the external

How Alferon N works

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.