Alertex

Alertex Uses, Dosage, Side Effects, Food Interaction and all others data.

Alertex is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Alertex activates glutamatergic circuits while inhibiting GABA.

Alertex is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Alertex is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction.

Trade Name Alertex
Availability Prescription only
Generic Modafinil
Modafinil Other Names Modafinil, Modafinilo, Modafinilum
Related Drugs Adderall, methylphenidate, Concerta, Ritalin, dextroamphetamine, amphetamine / dextroamphetamine, armodafinil, Provigil, Nuvigil, Sunosi
Type
Formula C15H15NO2S
Weight Average: 273.35
Monoisotopic: 273.082349419
Protein binding

60%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Alertex
Alertex

Uses

Alertex is a stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.

To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.

Alertex is also used to associated treatment for these conditions: Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance

How Alertex works

The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Alertex activates glutamatergic circuits while inhibiting GABA. Alertex is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Alertex has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

[Minor] Administration with food may delay the absorption of modafinil (the racemate) and armodafinil (the R-enantiomer) without significantly affecting their overall bioavailability.

According to the product labeling, modafinil's absorption may be delayed by approximately one hour if taken with food.

Similarly, the time to reach peak plasma concentration (Tmax) of armodafinil may be delayed by approximately 2 to 4 hours in the fed state.

Alertex Hypertension interaction

[Major] CNS stimulant medications have shown to increase blood pressure, and their use might be contraindicated in patients with severe hypertension.

Caution should be used when administering to patients with preexisting high blood pressure and other cardiovascular conditions.

All patients under treatment should be regularly monitored for changes in blood pressure and heart rate.

Volume of Distribution

  • 0.9 L/kg

Elimination Route

Rapid following oral administration.

Half Life

23-215 hours

Elimination Route

The major route of elimination is metabolism (~90%), primarily by the liver, with subsequent renal elimination of the metabolites.

Innovators Monograph

You find simplified version here Alertex

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0002279
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http://classyfire.wishartlab.com/tax_nodes/C0000369
http://classyfire.wishartlab.com/tax_nodes/C0004630
http://classyfire.wishartlab.com/tax_nodes/C0000491
http://classyfire.wishartlab.com/tax_nodes/C0001662
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http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=30125
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https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1373
http://www.pharmgkb.org/drug/PA450530
http://www.rxlist.com/cgi/generic2/modafinil.htm
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http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=pro1544.html&contentName=Provigil&contentId=631
https://en.wikipedia.org/wiki/Modafinil
*** Taking medicines without doctor's advice can cause long-term problems.
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