Alpha-dienestrol Diacetate

Alpha-dienestrol Diacetate Uses, Dosage, Side Effects, Food Interaction and all others data.

Alpha-dienestrol Diacetate is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis).

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Alpha-dienestrol Diacetate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Alpha-dienestrol Diacetate
Generic	Dienestrol
Dienestrol Other Names	alpha-dienestrol diacetate, Cycladiene, Dehydrostilbestrol, Dienestrol, Diènestrol, Dienestrolum
Type
Formula	C₁₈H₁₈O₂
Weight	Average: 266.34 Monoisotopic: 266.13067982
Protein binding	50 to 80%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Alpha-dienestrol Diacetate is a non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae.

For use in the treatment of atrophic vaginitis and kraurosis vulvae.

How Alpha-dienestrol Diacetate works

Alpha-dienestrol Diacetate is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA.

Toxicity

Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.

Elimination Route

Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).