N(1)-Pyridylsulfanilamide

N(1)-Pyridylsulfanilamide Uses, Dosage, Side Effects, Food Interaction and all others data.

Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.

N(1)-Pyridylsulfanilamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name N(1)-Pyridylsulfanilamide
Generic Sulfapyridine
Sulfapyridine Other Names 2-Sulfanilamidopyridin, 2-Sulfanilamidopyridine, 2-Sulfanilylaminopyridine, 2-Sulfapyridine, N(1)-Pyridylsulfanilamide, Solfapiridina, Sulfapiridina, Sulfapyridin, Sulfapyridine, Sulfapyridinum, Sulphapyridine
Type
Formula C11H11N3O2S
Weight Average: 249.289
Monoisotopic: 249.057197301
Protein binding

Approximately 50% bound to plasma proteins.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
N(1)-Pyridylsulfanilamide
N(1)-Pyridylsulfanilamide

Uses

N(1)-Pyridylsulfanilamide is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum.

For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum

How N(1)-Pyridylsulfanilamide works

N(1)-Pyridylsulfanilamide is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.

Toxicity

LD50 is 15800 mg/kg (orally in rats).

Elimination Route

Approximately 60-80%

Half Life

6-14 hours.

Innovators Monograph

You find simplified version here N(1)-Pyridylsulfanilamide

*** Taking medicines without doctor's advice can cause long-term problems.
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