Alredase

Alredase Uses, Dosage, Side Effects, Food Interaction and all others data.

Alredase (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. It was sold under the tradename Alredase but was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death.

Table Of contents

• Alredase
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Alredase
Generic	Tolrestat
Tolrestat Other Names	Tolrestat
Type
Formula	C16H14F3NO3S
Weight	Average: 357.347 Monoisotopic: 357.064648624
Groups	Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the pharmacological control of certain diabetic complications.

Toxicity

Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

Innovators Monograph

You find simplified version here Alredase